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2012
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng +3 more
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Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng +3 more
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Pharmacogenomics, 2010
In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study.
Patricia, Gassó +7 more
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In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study.
Patricia, Gassó +7 more
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Gene-Gene, Gene-Environment & Multiple Interactions in Colorectal Cancer
Journal of Environmental Science and Health, Part C, 2006This review comprehensively evaluates the influence of gene-gene, gene-environment and multiple interactions on the risk of colorectal cancer (CRC). Methods of studying these interactions and their limitations have been discussed herein. There is a need to develop biomarkers of exposure and of risk that are sensitive, specific, present in the pathway ...
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Gene-Gene Interaction and Epistasis
2011This chapter defines the differing meanings of the words gene-gene interaction and “epistasis”. Epistasis can be loosely defined as the interaction between two or more genes. The differences between biological and statistical epistasis are examined and the decomposition of genetic variance in any system into single-locus and epistatic components of ...
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Testing for Gene-Gene Interaction with AMMI Models
Statistical Applications in Genetics and Molecular Biology, 2010Studies have shown that many common diseases are influenced by multiple genes and their interactions. There is currently a strong interest in testing for association between combinations of these genes and disease, in particular because genes that affect the risk of disease only in the presence of another genetic variant may not be detected in marginal
Amina, Barhdadi, Marie-Pierre, Dubé
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Role of gene–gene/gene–environment interaction in the etiology of eastern Indian ADHD probands
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011Associations between attention deficit hyperactivity disorder (ADHD) and genetic polymorphisms in the dopamine receptors, transporter and metabolizing enzymes have been reported in different ethnic groups. Gene variants may affect disease outcome by acting synergistically or antagonistically and thus their combined effect becomes an important aspect to
Manali, Das +8 more
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Gene-gene interactions in myocardial infarction
The Lancet, 2006www.thelancet.com Vol 367 May 27, 2006 1729 Shirish Sheth (Jan 21, p 185) rightly decries the appalling fact that, as a result of abortion, “about 100 million girls are missing from the world—they are dead”, and properly emphasises that, since 1986, all members of the Federation of Obstetric and Gynaecological Societies of India have been “asked to ...
Gilles Pernod +2 more
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Detecting Gene‐Gene Interaction in Linkage Analysis
Current Protocols in Human Genetics, 2005AbstractLinkage analysis has been very successful in identifying genes for many Mendelian diseases, but has not enjoyed the same level of success for complex diseases. A major reason is that complex diseases are multifactorial, involving multiple genes and environmental factors.
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Gene-Gene and Gene-Environment Interactions
2018Identifying gene-gene and gene-environment interactions may help us to better describe the genetic architecture for complex traits. While advances have been made in identifying genetic variants associated with complex traits through more dense panels of genetic variants and larger sample sizes, genome-wide interaction analyses are still limited in ...
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Gene-gene interaction in asthma
American Journal of Human Genetics, 2002Asthma is a common respiratory disease that is characterized by variable airways obstruction caused by acute and chronic bronchial inflammation; associated phenotypes include bronchial hyperresponsiveness (BHR), elevated total serum immunoglobulin E (IgE) levels, and skin tests positive to common allergens.
Howard, TD +5 more
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