Results 71 to 80 of about 7,342,964 (293)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Identification of gene-gene interaction using principal components [PDF]
BMC Proceedings, 2009 Abstract After more than 200 genome-wide association studies, there have been some successful identifications of a single novel locus. Thus, the identification of single-nucleotide polymorphisms (SNP) with interaction effects is of interest.
Li, Jia +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Differences in Gene Expression between Sonoporation in Tumor and in Muscle
, 2010 Background Ultrasound (US) is a novel and effective tool for the local delivery of genes into target tissues. US can temporarily change the permeability of a cell membrane and thus enhance the delivery of naked DNA into cells.
TSAI, KUN-CHE;LIAO, ZHE-KANG;LIN, WIN-LI;SHIEH, MING-JIUM;HWAN,G LIH-HWA;CHEN, WEN-SHIANG +1 more
core +1 more source
Neighborhood-Based Clustering of Gene-Gene Interactions
, 2006 n this work, we propose a new greedy clustering algorithm to identify groups of related genes. Clustering algorithms analyze genes in order to group those with similar behavior. Instead, our approach groups pairs of genes that present similar positive and/or negative interactions. Our approach presents some interesting properties.
Norberto Díaz-Díaz +3 more
openaire +4 more sources
Study of Gene-Gene Interaction Networks
Journal of Nature, Science & Technology, 2021 Gene-Gene Interactions (GGI) Networks-Genomics essentially finds the driver node to understand the functional mechanism of Gene-Gene Interaction or GGI. This process can significantly improvise while examining molecular processes perturbed by genetics in human diseases.
openaire +1 more source
Gene-Drug Interaction in Stroke
Stroke Research and Treatment, 2011 Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors.
Serena Amici +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source