Results 61 to 70 of about 7,758,263 (304)

Gene-Gene and Gene-Environment Interactions in Mild Hyperhomocysteinemia [PDF]

Pathophysiology of Haemostasis and Thrombosis, 2003
Mild/moderate hyperhomocysteinemia (HHcy), a highly prevalent condition, is independently associated with an increased risk of arterial and venous thromboembolic diseases. Early reports of the association of mild/moderate HHcy with juvenile venous thromboembolism have shown familiarity for HHcy in relatives of index cases with thrombosis.
D'Angelo, Armando, Mazzola, Giuseppina, Fermo, Isabella   +2 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk

Annals of Medicine
Background Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart
Jianhui Wei, Peng Huang, Letao Chen, Tubao Yang, Tingting Wang, Ziye Li, Lizhang Chen, Jiabi Qin   +7 more
doaj   +1 more source

SnTox3 acts in effector triggered susceptibility to induce disease on wheat carrying the Snn3 gene [PDF]

, 2009
The necrotrophic fungus Stagonospora nodorum produces multiple proteinaceous host-selective toxins (HSTs) which act in effector triggered susceptibility.
McDonald, B., McDonald Megan C., Nunez, A., Faris Justin D., Liu, Z., Zhaohui Liu, Friesen Timothy L., Tan, Kar-Chun, Oliver, R.P., Faris, Justin D., Kar-Chun Tan, Oliver, Richard P., Rasmussen, Jack B., Lu Shunwen, Solomon Peter S., Richard P Oliver, Friesen, T., Tan, K.C., Megan C McDonald, McDonald, M., Oliver Richard P., Bruce A McDonald, Friesen, T.L., Jack B Rasmussen, McDonald, Megan C., McDonald, Megan C.; id_orcid, Faris, J.D., Peter S Solomon, Liu Zhaohui, Nunez, Alberto, McDonald, Bruce A., Rasmussen, J., Rasmussen Jack B., Friesen, Timothy L., Faris, J., McDonald Bruce A., Oliver, Richard, Liu, Zhaohui, McDonald, B.A., Rasmussen, J.B., Nunez Alberto, Solomon, Peter S., Tan Kar-Chun, Timothy L Friesen, Solomon, P., McDonald, M.C., Lu, S., Shunwen Lu, Justin D Faris, Alberto Nunez, Lu, Shunwen, Solomon, P.S.   +51 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

CREaTor: zero-shot cis-regulatory pattern modeling with attention mechanisms

Genome Biology, 2023
Linking cis-regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis-regulatory patterns for genomic elements up to 2 Mb from target genes ...
Yongge Li, Fusong Ju, Zhiyuan Chen, Yiming Qu, Huanhuan Xia, Liang He, Lijun Wu, Jianwei Zhu, Bin Shao, Pan Deng   +9 more
doaj   +1 more source

A realistic assessment of methods for extracting gene/protein interactions from free text [PDF]

, 2009
Background: The automated extraction of gene and/or protein interactions from the literature is one of the most important targets of biomedical text mining research.
Kabiljo, R., Clegg, AB, Renata Kabiljo, Shepherd, AJ, Kabiljo Renata, Clegg Andrew B, Andrew B Clegg, Shepherd Adrian J, Shepherd, Adrian J., Kabiljo, R, Clegg, A.B., Adrian J Shepherd   +11 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Gene-gene interaction network.

The identified miR target genes were analysed by means of a gene-gene interaction network using functional protein association networks software (String and Cytoscape software). The nodes in the networks are sized by their node degree. (TIF)
Marzia Rossato (3424763), Cristina Beltrami (2634700), Marco Tomasetti (293754), Federica Monaco (826196), Lory Santarelli (293775), Monica Amati (353759), Giacomo Sollini (17781413), Ernesto Pasquini (5754995), Massimo Re (5754986), Gaia Goteri (590527), Corrado Rubini (10527), Concetta De Quattro (17781410)   +11 more
core   +1 more source

Gene-environment interaction models identified by the GMDR method with adjustment for age and gender.

, 2017
Gene-environment interaction models identified by the GMDR method with adjustment for age and gender.
Chung-Feng Kao (104445), Po-Hsiu Kuo (104448), Yu-Li Liu (175348), Shih-Jen Tsai (160992), Albert C. Yang (222158), Eugene Lin (759907)   +5 more
core   +1 more source