Results 61 to 70 of about 7,342,964 (293)

Gene-gene interactions in gastrointestinal cancer susceptibility

Oncotarget, 2016
Cancer arises from complex, multi-layer interactions between diverse genetic and environmental factors. Genetic studies have identified multiple loci associated with tumor susceptibility. However, little is known about how germline polymorphisms interact with one another and with somatic mutations within a tumor to mediate acquisition of cancer traits.
Kim, Jineun, Yum, Seoyun, Kang, Changwon, Kang, Suk-Jo   +3 more
openaire   +3 more sources

Gene-Gene and Gene-Environment Interactions in Mild Hyperhomocysteinemia [PDF]

Pathophysiology of Haemostasis and Thrombosis, 2003
Mild/moderate hyperhomocysteinemia (HHcy), a highly prevalent condition, is independently associated with an increased risk of arterial and venous thromboembolic diseases. Early reports of the association of mild/moderate HHcy with juvenile venous thromboembolism have shown familiarity for HHcy in relatives of index cases with thrombosis.
D'Angelo, Armando, Mazzola, Giuseppina, Fermo, Isabella   +2 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Identification and characterization of human PCDH10 gene promoter

, 2011
Recent studies have suggested roles for PCDH10 as a novel tumor suppressor gene. In our previous work, we located the core promoter of PCDH10 to a 462-bp segment of 5'-flanking region characterized by a high GC content.
Cai, Zhiming, Li, Zesong, Zesong Li, Aifa Tang, Jiongxian Ye, Li, Wenjie, Jun Xie, Li, Xianxin, Wenjie Li, Yonghua Han, Xie, Jun, Xianxin Li, Gui, Yaoting, Han, Yonghua, Jing, Jie, Jie Jing, Ye, Jiongxian, Zhiming Cai, Yaoting Gui, Jiang, Zhimao, Tang, Aifa, Zhimao Jiang   +21 more
core   +1 more source

Gene-Gene Interaction Analysis In Alzheimer

International Journal of Computer Science and Information Technology, 2018
ABSTRACT Genome-wide transcription profiling is a powerful technique in studying disease susceptible footprints. Moreover, when applied to disease tissue it may reveal quantitative and qualitative alterations in gene expression that give information on the context or underlying basis for the disease and may provide a new diagnostic approach.
Rishi Yadav, Ravi Bhushan Mishra
openaire   +3 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Stria Gravidarum Is Genetic But Not Related With Collagen Gene Polymorphism [PDF]

, 2013
BACKGROUND: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG.
Gungor, Cakir A. N., Gencer, M., Silan, F., Uysal, A., Isik, S., Oguz, S., Uludag, A.   +6 more
core   +1 more source

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk

Annals of Medicine
Background Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart
Jianhui Wei, Peng Huang, Letao Chen, Tubao Yang, Tingting Wang, Ziye Li, Lizhang Chen, Jiabi Qin   +7 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

CREaTor: zero-shot cis-regulatory pattern modeling with attention mechanisms

Genome Biology, 2023
Linking cis-regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis-regulatory patterns for genomic elements up to 2 Mb from target genes ...
Yongge Li, Fusong Ju, Zhiyuan Chen, Yiming Qu, Huanhuan Xia, Liang He, Lijun Wu, Jianwei Zhu, Bin Shao, Pan Deng   +9 more
doaj   +1 more source