Results 191 to 200 of about 7,655,843 (235)

Differential gene expression in trabecular bone osteocytes is related to the local strain and strain gradient. [PDF]

Sci Rep
Machireddy M, Nano S, Debiase L, Lewis J, Cole S, Li J, Niebur GL.   +6 more
europepmc   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Genome-Wide Identification of <i>Ginkgo biloba</i> SPL Gene Family and Expression Analysis in Flavonoid Biosynthesis and Water Stress. [PDF]

Int J Mol Sci
Ming M, Yi M, Qin C, Yan L, Sun Y, Zhang J, Cao F, Fu F.   +7 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Correction: Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease. [PDF]

PLoS One
Sæterstad S, Østvik AE, Røyset ES, Bakke I, Sandvik AK, Granlund AVB.   +5 more
europepmc   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Inferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for <i>Tetrahymena thermophila</i>. [PDF]

NAR Genom Bioinform
Bertagna MA, Bright LJ, Ye F, Jiang YY, Sarkar D, Pradhan A, Kumar S, Gao S, Turkewitz AP, Tsypin LMZ.   +9 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Genome-Wide Analysis of the Caffeoyl Coenzyme A-O-Methyltransferase (<i>CCoAOMT</i>) Gene Family in <i>Platycodon grandiflorus</i> (Jacq.) A. DC. and the Potential Regulatory Mechanism in Response to Copper Stress. [PDF]

Int J Mol Sci
Ma J, Jiang S, Kong L, Ma L, Wang X, Pan M, Li C, Huang S, Liu X, Ma W, Ren W.   +10 more
europepmc   +1 more source

Utilization of Native CRISPR-Cas9 System for Expression of Glucagon-like Peptide-1 in <i>Lacticaseibacillus paracasei</i>. [PDF]

Foods
Zheng M, Zhang S, Wang Y, Xie N, Wang X, Lv J, Pang X, Li X.   +7 more
europepmc   +1 more source