Results 271 to 280 of about 5,291,226 (319)

Analysis of Gene‐Gene Interactions

Current Protocols in Human Genetics, 2017
AbstractThe goal of this unit is to introduce epistasis, or gene‐gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene‐gene interactions ...
Brian S, Cole, Molly A, Hall, Ryan J, Urbanowicz, Diane, Gilbert-Diamond, Jason H, Moore   +4 more
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Genes and Gene Expression

Clinical Orthopaedics and Related Research, 2000
Gene therapy is the process whereby a therapeutic protein is synthesized from a DNA molecule (gene) that has been inserted into the cells. The goal is to produce the desired protein in the proper quantity in the proper location. Successful designing of vectors for gene therapy requires knowledge of gene structure and regulation.
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Gene-Gene and Gene-Environment Interactions

2018
Identifying gene-gene and gene-environment interactions may help us to better describe the genetic architecture for complex traits. While advances have been made in identifying genetic variants associated with complex traits through more dense panels of genetic variants and larger sample sizes, genome-wide interaction analyses are still limited in ...
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Gene-Gene Interactions

2012
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng, Yaning Yang, Xiaofeng Zhu, Robert C. Elston   +3 more
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Genes within genes within bacteria

Trends in Biochemical Sciences, 2003
Recently, an unusual gene structure has been described in species of the genus Thermus, in which the rpmH (ribosomal protein L34) coding sequence was found to be entirely overlapped by the unusually large rnpA (RNase P protein subunit) sequence. Gene overlap is common in viruses, but has not been seen to this extent in any bacterium.
J Christopher, Ellis, James W, Brown
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Genes within Genes

Inference: International Review of Science, 2018
A new study, “Russian Doll Genes and Complex Chromosome Rearrangements in Oxytricha trifallax,” casts fresh light on gene nesting and mathematical patterns. Tyler Hampton examines the key findings.
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Songs of Genes, by Genes, for Genes

Leonardo, 2012
The authors have defined a new concept of “base_position” and translated the protein-coding sequence to a sequence consisting of 12 base_positions. The authors developed a new algorithm for translating the base_position sequence to a melody with a range of at most a twelfth and without leaps larger than an octave, which should be turned upside-down by
Dongya Ge, Yixue Li
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Analysis of Gene‐Gene Interactions

Current Protocols in Human Genetics, 2003
AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
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Tandem genes and clustered genes

Journal of Theoretical Biology, 1995
Two patterns of gene repetition are described: tandem arraying and clustering. Tandemly arrayed genes reside within segments of DNA that are repeated head-to-tail a number of times. Clustered genes are linked but irregularly spaced, are often mutually inverted in an unpredictable pattern and are connected by non-conserved DNA.
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