Results 41 to 50 of about 908,057 (316)

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Gene action and standard heterosis over environments in Rice (Oryza sativa L.) [PDF]

Electronic Journal of Plant Breeding, 2014
The present study on genetic components of variance carried over individual and pooled environments for thirteen metric traits in rice revealed the greater magnitude of dominance component than corresponding additive component of variance, thereby ...
Sajad Hussain Dar, A.G. Rather, S.Najeeb*, N.A. Zeerak, Asif B. Shikari, Z.A. Bhat, M.A. Ahanger, S.D. Mir, Mushtaq Ahmad, Shahida Iqbal, Iram Saba and Gazala Hassan
doaj  

Effect of Heritability, Genetic Advance and Correlation on Yield Contributing Traits in Upland Cotton

Journal of Agricultural Sciences, 2021
This research was planned to study the heritability (broad sense), correlation, genetic advance and behavior of different characters in segregating population of upland cotton.
Muhammad Bhutta, Muhammad Kamran Qureshi, Muhammad Ishaq, Ali Hassan, Sana Munir, Ahmad Shahzad, Muhammad Anjam   +6 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Yield assessment of new streak-resistant topcross maize hybrids in Benin

Open Agriculture
Maize (Zea mays L.) is the foremost cereal consumed in Benin but its production is constrained by the lack of access to high-quality seeds for intensification of the crop; hence, the continued cultivation of disease-susceptible, low-yielding, and open ...
Emeraghi Mary, Iseghohi Innocent, Idohou Jacob, Mkpuma Kenneth C., Agbandou Pinawé C., Afouda Leonard, Akponikpe Pierre I., Hotegni Nicodeme V. Fassinou, Missihoun Antoine A., Oselebe Happiness, Achigan-Dako Enoch G.   +10 more
doaj   +1 more source

Broad-Spectrum Resistance and Monogenic Inheritance of Bacterial Blight Resistance in an Indigenous Upland Rice Germplasm ULR207

Agronomy
Bacterial blight (BB) caused by Xanthomonas oryzae pv. Oryzae (Xoo) is a serious disease of rice worldwide that can reduce crop yield and affect food insecurity. A rice resistance variety is an alternate way to solve this problem.
Tanawat Wongsa, Sompong Chankaew, Tidarat Monkham, Jirawat Sanitchon   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source