Results 191 to 200 of about 1,302,502 (304)

IncL plasmid-mediated dissemination of OXA-48 β-lactamase and bla _CTX-M-15 gene amplification identified via long-read sequencing in carbapenem-resistant Enterobacterales. [PDF]

JAC Antimicrob Resist
Prasad S, Dratvova B, Gryndlerova A, Brajerova M, Kabelikova P, Tkadlec J, Drevinek P, Krutova M.   +7 more
europepmc   +1 more source

Gene Amplification and the Extrachromosomal Circular DNA. [PDF]

Genes (Basel), 2021
Shimizu N.
europepmc   +1 more source

FANCA Gene Amplification [PDF]

, 2020
openaire   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Template switching during DNA replication is a prevalent source of adaptive gene amplification. [PDF]

Elife
Chuong JN, Ben Nun N, Suresh I, Matthews JC, De T, Avecilla G, Abdul-Rahman F, Brandt N, Ram Y, Gresham D.   +9 more
europepmc   +1 more source

Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor. [PDF]

Gynecol Oncol, 2023
McNamara B, Harold J, Manavella D, Bellone S, Mutlu L, Hartwich TMP, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa MSZ, Yang K, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Burton EA, Inagaki H, Albers A, Zhang C, Bollag G, Schlessinger J, Santin AD.   +28 more
europepmc   +1 more source

FGFR Gene Amplification [PDF]

, 2020
openaire   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

ZNF217 Gene Copy Number as a Marker of Response to Standard Therapy Drugs According to ERα Status in Breast Cancer

Breast Cancer: Targets and Therapy
Nelson Rangel,1 Iris Lorena Sánchez,2 Duván Sebastián Valbuena,2 Milena Rondón-Lagos2 1Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, 110231, Colombia; 2School of Biological Sciences, Universidad ...
Rangel N, Sánchez IL, Valbuena DS, Rondón-Lagos M   +3 more
doaj  

Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events. [PDF]

NPJ Antimicrob Resist
Kupke J, Brombach J, Fang Y, Wolf SA, Thrukonda L, Ghazisaeedi F, Kuropka B, Hanke D, Semmler T, Nordholt N, Schreiber F, Tedin K, Lübke-Becker A, Steiner UK, Fulde M.   +14 more
europepmc   +1 more source