Results 211 to 220 of about 860,814 (258)

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

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Gene amplification in cancer

Trends in Genetics, 2006
Gene amplification is a copy number increase of a restricted region of a chromosome arm. It is prevalent in some tumors and is associated with overexpression of the amplified gene(s). Amplified DNA can be organized as extrachromosomal elements, as repeated units at a single locus or scattered throughout the genome.
openaire   +2 more sources

GENE AMPLIFICATION IN LEISHMANIA

Annual Review of Microbiology, 1991
INTRODUCTION . . . . . . . . . . . . .. . .... . . .... . . . . . . . . . . . . . . . . . . . . . .. . ... . . . .. . . . .. . . .. . . .. .. . .. . . . . . . . . . . 417 A Leishmania Primer 4 1 8 The Leishmania Genome and Circular DNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
openaire   +2 more sources

Is Gene Amplification RNA-directed?

Nature New Biology, 1973
Gene amplification in oocytes has been thought to involve a “reverse transcriptase” like that found in the RNA tumour viruses. Neither the template RNA nor the hybrid intermediates required by this theory can be detected in amplifying ovaries.
A, Bird, E, Rogers, M, Birnstiel
openaire   +2 more sources

Regulation and mechanisms of gene amplification

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995
Abstract Amplification in rodent cells usually involves bridge-breakage-fusion (bbf) cycles initiated either by endto-end fusion of sister chromatids, or by chromosome breakage. In contrast, in human cells, resistance to the antimetabolite A-(phosphonacetyl)-L-aspartate (PALA) can be mediated by several different mechanisms that lead ...
K A, Smith, M L, Agarwal, M V, Chernov, O B, Chernova, Y, Deguchi, Y, Ishizaka, T E, Patterson, M F, Poupon, G R, Stark   +8 more
openaire   +2 more sources

Induction of Gene Amplification by Arsenic

Science, 1988
Arsenic is a well-established carcinogen in humans, but there is little evidence for its carcinogenicity in animals and it is inactive as an initiator or tumor promoter in two-stage models of carcinogenicity in mice. Two arsenic salts (sodium arsenite and sodium arsenate) induced a high frequency of methotrexate-resistant 3T6 cells, which were shown to
T C, Lee, N, Tanaka, P W, Lamb, T M, Gilmer, J C, Barrett   +4 more
openaire   +2 more sources

Alternative Model for Gene Amplification

Nature New Biology, 1971
The number of nucleoli increases shortly after the conversion of germ cells into oogonia or spermatogonia in Xenopus laevis. This event demands a modification of the theory of gene amplification. A new explanation is proposed which involves non-chromosomal genes restricted to the germ-line.
H, Wallace, J, Morray, W H, Langridge
openaire   +2 more sources

Gene Amplification and Insecticide Resistance

Annual Review of Entomology, 1991
Recapitulation des travaux portant sur le mecanisme de resistance des insectes face aux substances toxiques, base sur l'amplification des genes de resistance.
A L, Devonshire, L M, Field
openaire   +2 more sources

GENE AMPLIFICATION

Annual Review of Biochemistry, 1984
G R, Stark, G M, Wahl
  +6 more sources