Results 221 to 230 of about 8,013,600 (393)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Gene Amplification and the Extrachromosomal Circular DNA. [PDF]

Genes (Basel), 2021
Shimizu N.
europepmc   +1 more source

Erratum: Expression and amplification of the N-myc gene in primary retinoblastoma [PDF]

, 1984
W.-H. Lee, A. Linn Murphree, W. F. Benedict   +2 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification. [PDF]

Cell Genom
Wala J, Dalin S, Webster S, Shapira O, Busanovich J, Sarmashghi S, Beroukhim R, Bandopadhayay P, Rendo V.   +8 more
europepmc   +1 more source

An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae. [PDF]

Nat Commun, 2022
Peng B, Esquirol L, Lu Z, Shen Q, Cheah LC, Howard CB, Scott C, Trau M, Dumsday G, Vickers CE.   +9 more
europepmc   +1 more source

Identification and amplification of theE. coli phrgene product [PDF]

, 1983
Gwendolyn B. Sancar, Frances W. Smith, Aziz Sancar   +2 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events. [PDF]

NPJ Antimicrob Resist
Kupke J, Brombach J, Fang Y, Wolf SA, Thrukonda L, Ghazisaeedi F, Kuropka B, Hanke D, Semmler T, Nordholt N, Schreiber F, Tedin K, Lübke-Becker A, Steiner UK, Fulde M.   +14 more
europepmc   +1 more source

BRCA gene amplification in primary peritoneal high-grade serous carcinoma patient with intrinsic resistance to platinum treatment: a case report. [PDF]

Pathologica, 2023
Buttitta F, Di Marino P, Felicioni L, Primavera FC, Ferro B, Zampacorta C, Pasciuto MP, Rossetti R, Tudini M, Marchetti A, D'Angelo E.   +10 more
europepmc   +1 more source