Results 241 to 250 of about 8,013,600 (393)

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, Volume 19, Issue 5, Page 1493-1507, May 2025.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

GLPp16 gene amplification induces susceptibility to high-grade urothelial carcinoma. [PDF]

Front Oncol
Liu Y, Sun Q, Long H, Zhang D, Zheng J, Zhang H.   +5 more
europepmc   +1 more source

Gene amplification and overexpression of EGF receptor in squamous cell carcinomas of the head and neck

, 1989
J. Ishitoya, Michinori Toriyama, Naohiko OGUCHI, Kazuya Kitamura, Mikiko Ohshima, Kazushi Asano, Tadashi Yamamoto   +6 more
openalex   +2 more sources

Gene amplification in methotrexate-resistant mouse cells. IV. Different DNA sequences are amplified in different resistant lines [PDF]

, 1982
Ruggiero Caizzi, Christopher J. Bostock
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Optimizing a modified cetyltrimethylammonium bromide protocol for fungal DNA extraction: Insights from multilocus gene amplification. [PDF]

Open Life Sci
Dar GJ, Nazir R, Wani SA, Farooq S, Aziz T, Albekairi TH.   +5 more
europepmc   +1 more source

Prevalence of Closely Related Candida albicans Species among Patients with Vulvovaginal Candidiasis in Southern Poland Based on the hwp1 Gene Amplification. [PDF]

Pol J Microbiol, 2023
Klesiewicz K, Mrowiec P, Kania K, Skiba-Kurek I, Białecka J, Namysł M, Małek M.   +6 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Design and Optimization of Isothermal Gene Amplification for Generation of High-Gain Oligonucleotide Products by MicroRNAs. [PDF]

ACS Meas Sci Au
Lee J, Han J, Song Y, Gu B, Kim E.
europepmc   +1 more source

Amplification of D-xylose and D-glucose isomerase activities in Escherichia coli by gene cloning [PDF]

, 1983
Merle G. Wovcha, D L Steuerwald, Katherine Brooks   +2 more
openalex   +1 more source