Results 171 to 180 of about 566,833 (345)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Protocol for gene annotation, prediction, and validation of genomic gene expansion. [PDF]
STAR Protoc, 2022 Zhang Q, Zhang ZD.
europepmc +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
PrismEXP: gene annotation prediction from stratified gene-gene co-expression matrices. [PDF]
PeerJ, 2023 Lachmann A +5 more
europepmc +1 more source
Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. [PDF]
, 2005 Hubert Hackl +8 more
openalex +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
DIG--a system for gene annotation and functional discovery [PDF]
, 2005 Marilyn DeLong +9 more
openalex +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Nematode gene annotation by machine-learning-assisted proteotranscriptomics enables proteome-wide evolutionary analysis. [PDF]
Genome Res, 2023 Ceron-Noriega A +3 more
europepmc +1 more source
Large-scale prokaryotic gene prediction and comparison to genome annotation [PDF]
, 2005 Pernille Nielsen, Anders Krogh
openalex +1 more source