Results 241 to 250 of about 7,510,778 (382)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

DeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation. [PDF]

Bioinformatics
Dohmen E, Aubel M, Eicholt LA, Roginski P, Luria V, Karger A, Grandchamp A.   +6 more
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Annotation matters: the effect of structural gene annotation on orthology inference. [PDF]

Bioinformatics
Prieto-Baños S, Nevers Y, Altenhoff A, Warwick Vesztrocy A, Dessimoz C, Glover NM.   +5 more
europepmc   +1 more source

Protocol for using NoBadWordsCombiner to merge and minimize "bad words" from BLAST hits against multiple eukaryotic gene annotation databases. [PDF]

STAR Protoc, 2021
Zhang X, Hu Y, Smith DR.
europepmc   +1 more source

CESAR 2.0 substantially improves speed and accuracy of comparative gene annotation

Bioinform., 2017
Virag Sharma, Peter Schwede, M. Hiller
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The community-curated Pristionchus pacificus genome facilitates automated gene annotation improvement in related nematodes. [PDF]

BMC Genomics, 2021
Rödelsperger C.
europepmc   +1 more source

Gene annotation of Isoetes hypsophila genome.

Liu, Chenlai
openalex   +1 more source

Additional file 9: of Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues

, 2018
Tao Tan, Xia Lin, Kailing Tu, Jie Tang, Senlin Yin, Lunzhi Dai, Lei Peng, Biao Dong, Hongbo Hu, Yong Fan, Yang Yu, Dan Xie   +11 more
openalex   +1 more source