Results 251 to 260 of about 7,510,778 (382)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Chromosome-level assembly and gene annotation of Kappaphycus striatus genome. [PDF]

Sci Data
Zhou Z, Ma Y, Zhang J, Firdaus M, Roleda MY, Duan D.   +5 more
europepmc   +1 more source

Uncovering transcriptional dark matter via gene annotation independent single-cell RNA sequencing analysis. [PDF]

Nat Commun, 2021
Wang MFZ, Mantri M, Chou SP, Scuderi GJ, McKellar DW, Butcher JT, Danko CG, De Vlaminck I.   +7 more
europepmc   +1 more source

Annotation of Seriola Lalandi reference transcriptome of larvae and diferential gene expression between normal and skeletal deformed individuals

, 2018
Ankitabahen Atulkumar Patel, E. Hernández, Vincent Barra, Víctor Martínez Moncada   +3 more
openalex   +1 more source

Incorporating Gene Annotation into Genomic Prediction of Complex Phenotypes

Genetics, 2017
N. Gao, J. Martini, Zhe Zhang, Xiaolong Yuan, Hao Zhang, H. Simianer, Jiaqi Li   +6 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Aliarcobacter butzleri gene annotation and transcriptome data

, 2022
Davide Buzzanca, Valentina Alessandria, Cristian Botta, Ilario Ferrocino, Kurt Houf, Kalliopi Rantsiou   +5 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Chromosome-scale genome assembly and gene annotation of the hydrothermal vent annelid Alvinella pompejana yield insight into animal evolution in extreme environments. [PDF]

BMC Biol
Hilali SE, Dru P, Le Moan A, Li YI, Huynen MA, Hoelz A, Robinson RC, Martín-Durán JM, Jollivet D, Claridge-Chang A, Copley RR.   +10 more
europepmc   +1 more source

Table S1. Primers used in the functional gene study;Table S2. Primers for dsRNA synthesis;Table S3. Summary of transcriptome sequencing and assembly for A. parthenogenetica;Table S4. The annotation results between unigenes and seven databases ;Table S5. The similar species and Genbank of VgR were compared by NCBI from Patio-temporal patterns of ovarian development and Very gene silencing reduced fecundity in parthenogenetic Artemia

, 2023
Hu Duan, Xuanxuan Shao, Wei Liu, Jianhai Xiang, Namin Pan, Xuehui Wang, Guoru Du, Ying Li, Jiaping Zhou, Liying Sui   +9 more
openalex   +1 more source