Results 261 to 270 of about 7,510,778 (382)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Chromosome-scale genome assembly and gene annotation of the Alligator Gar (Atractosteus spatula). [PDF]

Sci Data
Wang Q, Yu Q, Dong X, Chen H, Tian X, Qi P, Wu H, Yuan Y.   +7 more
europepmc   +1 more source

Functional annotation of predicted genes from Hiroshima-derived Magallana gigas

Imai, Misako
openalex   +1 more source

Enrichment of differentially expressed gene signatures in Hallmark functional annotation categories.

, 2016
Roman Kosoy, Charuta Agashe, Grishin Alexander, Y. Leung Donald, Wood Robert A., Sicherer Scott H., Jones Stacie M., Burks A. Wesley, Davidson Wendy F., Lindblad Robert W., Dawson Peter, M.S. Merad, A. Kidd Brian, T. Dudley Joel, A. Sampson Hugh, Cecilia Berin M.   +15 more
openalex   +2 more sources

Transcriptome assembly and annotation of johnsongrass ( Sorghum halepense ) rhizomes identify candidate rhizome‐specific genes [PDF]

, 2018
Nathan Ryder, Kevin Dorn, Mark Huitsing, Micah Adams, Jeff Ploegstra, Lee DeHaan, Steve Larson, Nathan Tintle   +7 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The battle for user-friendly bioinformatics

Frontiers in Genetics, 2013
David Roy Smith
doaj   +1 more source

Identification of Cocconeis neothumensis var. marina using a polyphasic approach including ultrastructure and gene annotation. [PDF]

PLoS One
Somma E, Costantini M, Pennesi C, Ruocco N, De Castro O, Terlizzi A, Zupo V.   +6 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Biologically-informed killer cell immunoglobulin-like receptor gene annotation tool. [PDF]

Bioinformatics
Ford MKB, Hari A, Zhou Q, Numanagić I, Sahinalp SC.   +4 more
europepmc   +1 more source