Results 281 to 290 of about 7,510,778 (382)

The state of play in higher eukaryote gene annotation

open access: yesNature reviews genetics, 2016
Jonathan M. Mudge, J. Harrow
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Improvements in viral gene annotation using large language models and soft alignments. [PDF]

open access: yesBMC Bioinformatics
Harrigan WL   +5 more
europepmc   +1 more source

N. sing1 Alginate Lyase (ALY) gene and domain annotation.

open access: green
Zeng Hao Lim (16989901)   +5 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Contigs directed gene annotation (ConDiGA) for accurate protein sequence database construction in metaproteomics. [PDF]

open access: yesMicrobiome
Wu E   +8 more
europepmc   +1 more source

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