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Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription [PDF]
Frontiers in Molecular Biosciences, 2021 Introns impact several vital aspects of eukaryotic organisms like proteomic plasticity, genomic stability, stress response and gene expression. A role for introns in the regulation of gene expression at the level of transcription has been known for more ...
Katherine Dwyer +3 more
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Intronization Signatures in Coding Exons Reveal the Evolutionary Fluidity of Eukaryotic Gene Architecture [PDF]
Microorganisms, 2022 The conventionally clear distinction between exons and introns in eukaryotic genes is actually blurred. To illustrate this point, consider sequences that are retained in mature mRNAs about 50% of the time: how should they be classified?
Judith Ryll +2 more
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Controlling gene expression timing through gene regulatory architecture. [PDF]
PLoS Computational Biology, 2022 Gene networks typically involve the regulatory control of multiple genes with related function. This connectivity enables correlated control of the levels and timing of gene expression.
Md Zulfikar Ali, Robert C Brewster
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Evo-Devo Algorithms: Gene-Regulation for Digital Architecture [PDF]
Biomimetics, 2019 The majority of current visual-algorithmic architecture is constricted to specific parameters that are gradient related, keeping their parts’ relation fixed within the algorithm, far away from a truly parametric modeling with a flexible topology ...
Diego Navarro-Mateu, Ana Cocho-Bermejo
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Evolutionary plasticity of developmental gene regulatory network architecture [PDF]
Proceedings of the National Academy of Sciences, 2007 Sea stars and sea urchins evolved from a last common ancestor that lived at the end of the Cambrian, approximately half a billion years ago. In a previous comparative study of the gene regulatory networks (GRNs) that embody the genomic program for ...
Britten +25 more
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PLoS ONEThe evolution of lineage-specific gene families remains poorly studied across the eukaryotic tree of life, with most analyses focusing on the recent evolution of de novo genes in model species.
Xyrus X Maurer-Alcalá +3 more
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Chromosome architecture constrains horizontal gene transfer in bacteria.
PLoS Genetics, 2018 Despite significant frequencies of lateral gene transfer between species, higher taxonomic groups of bacteria show ecological and phenotypic cohesion. This suggests that barriers prevent panmictic dissemination of genes via lateral gene transfer. We have
Heather L Hendrickson +3 more
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Genetic architecture of gene expression in the chicken [PDF]
BMC Genomics, 2013 Background The annotation of many genomes is limited, with a large proportion of identified genes lacking functional assignments. The construction of gene co-expression networks is a powerful approach that presents a way of integrating information from ...
Stanley Dragana +3 more
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Architecture and expression of the Nfatc1 gene in lymphocytes [PDF]
Frontiers in Immunology, 2014 In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase ...
Ronald eRudolf +7 more
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Unraveling the Shared Genetic Architecture and Polygenic Overlap Between Loneliness, Major Depressive Disorder, and Sleep-Related Traits [PDF]
BiomedicinesBackground: Loneliness (LON) is a heritable psychosocial trait that frequently co-occurs with major depressive disorder (MDD) and sleep traits. Despite known genetic contributions, the shared genetic architecture and molecular mechanisms underlying their
Zainab Rehman +11 more
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