Results 151 to 160 of about 754,180 (340)

The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters

Journal of Natural Products
AbstractBacteria produce diverse bioactive metabolites with ecological and pharmaceutical importance. These compounds are synthesized by biosynthetic gene clusters (BGCs), whose expression is tightly regulated. While many studies have examined the factors influencing BGC expression, including transcription factors (TFs) and environmental signals, the ...
Ribeiro Monteiro, Silvia, Kerdel, Yasmine, Gathot, Julianne, Rigali, Sébastien   +3 more
openaire   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Single Nucleotide Polymorphism–Single Nucleotide Polymorphism Interactions Among Inflammation Genes in the Genetic Architecture of Blood Pressure in the Framingham Heart Study [PDF]

, 2014
Jacob Basson, Lisa de las Fuentes, D. C. Rao   +2 more
openalex   +1 more source

Promoter architecture links gene duplication with transcriptional divergence [PDF]

, 2021
Evgeny Fraimovitch, Tzachi Hagai
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Ex-vivo Gene Therapy Restores LEKTI Activity and Corrects the Architecture of Netherton Syndrome-derived Skin Grafts [PDF]

, 2010
Wei‐Li Di, Fernado Larcher, Ekaterina Semenova, Gill E Talbot, John Harper, Marcela Del Río, Adrian J. Thrasher, Waseem Qasim   +7 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architecture [PDF]

, 2017
Víctor J. Díaz, Inma Castilla‐Cortázar, Irene Martín‐Estal, Mariano García‐Magariño, Gabriel A. Aguirre, JE Puche, RG de la Garza, LA Morales, Úrsula Muñoz   +8 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Unique Bipolar Gene Architecture in the RNA Genome of Influenza A Virus. [PDF]

Biochemistry (Mosc), 2020
Zhirnov OP.
europepmc   +1 more source