Results 11 to 20 of about 322,007 (305)
Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription [PDF]
Frontiers in Molecular Biosciences, 2021 Introns impact several vital aspects of eukaryotic organisms like proteomic plasticity, genomic stability, stress response and gene expression. A role for introns in the regulation of gene expression at the level of transcription has been known for more ...
Katherine Dwyer +3 more
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Intronization Signatures in Coding Exons Reveal the Evolutionary Fluidity of Eukaryotic Gene Architecture [PDF]
Microorganisms, 2022 The conventionally clear distinction between exons and introns in eukaryotic genes is actually blurred. To illustrate this point, consider sequences that are retained in mature mRNAs about 50% of the time: how should they be classified?
Judith Ryll +2 more
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Controlling gene expression timing through gene regulatory architecture. [PDF]
PLoS Computational Biology, 2022 Gene networks typically involve the regulatory control of multiple genes with related function. This connectivity enables correlated control of the levels and timing of gene expression.
Md Zulfikar Ali, Robert C Brewster
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Genetic architecture of gene expression in the chicken [PDF]
BMC Genomics, 2013 Background The annotation of many genomes is limited, with a large proportion of identified genes lacking functional assignments. The construction of gene co-expression networks is a powerful approach that presents a way of integrating information from ...
Stanley Dragana +3 more
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Architecture and expression of the Nfatc1 gene in lymphocytes [PDF]
Frontiers in Immunology, 2014 In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase ...
Ronald eRudolf +7 more
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Nuclear architecture and gene regulation
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008 The spatial organization of eukaryotic genomes in the cell nucleus is linked to their transcriptional regulation. In mammals, on which this review will focus, transcription-related chromatin positioning is regulated at the level of chromosomal sub-domains and individual genes. Most of the chromatin remains stably positioned during interphase.
Elena Fedorova, Daniele Zink
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Insulators: linking genome architecture to gene regulation [PDF]
F1000 Biology Reports, 2009 Insulator elements have long been associated with a proposed domain boundary function, ensuring appropriate associations between regulatory elements and transcription units through the physical organisation of the genome into looped domains. Recent experiments in Drosophila have, however, highlighted a more direct involvement of insulators in ...
Robert A. White
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Dissecting the regulatory architecture of gene expression QTLs [PDF]
Genome Biology, 2012 Abstract Background Expression quantitative trait loci (eQTLs) are likely to play an important role in the genetics of complex traits; however, their functional basis remains poorly understood. Using the HapMap lymphoblastoid cell lines, we combine 1000 Genomes genotypes and an extensive catalogue of ...
Daniel J. Gaffney +8 more
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Integration of the Gene Ontology into an object-oriented architecture [PDF]
BMC Bioinformatics, 2005 Background To standardize gene product descriptions, a formal vocabulary defined as the Gene Ontology (GO) has been developed. GO terms have been categorized into biological processes, molecular functions, and cellular components.
Zheng W Jim, Shegogue Daniel
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The architecture of the gene regulatory networks of different tissues [PDF]
Bioinformatics, 2012 Abstract Summary: The great variety of human cell types in morphology and function is due to the diverse gene expression profiles that are governed by the distinctive regulatory networks in different cell types. It is still a challenging task to explain how the regulatory networks achieve the diversity of different cell types.
Jie Li +4 more
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