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Regulatory architecture of cell identity genes and housekeeping genes
Trends in Cell Biology, 2023Gene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping genes are often regulated through clustering of promoters. We discuss here new regulatory insights for these two types of genes.
Alessandra, Dall'Agnese, Richard, Young
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Genes controlling plant architecture
Current Opinion in Biotechnology, 2006Plant architecture, referring here to the aerial part of a higher plant, is mainly determined by factors affecting shoot branching, plant height and inflorescence morphology. Significant progress has been made in isolating and characterizing genes that are directly involved in the formation of plant architecture, especially those controlling the ...
Yonghong Wang, Jiayang Li
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Chromatin architecture is a flexible foundation for gene expression
Nature Genetics, 2021The structure of chromatin is associated with its function, but precisely how is unclear. New data show that the higher-order architecture of the genome is similar among cell types with widely variant fates and gene expression patterns, thus challenging the view that chromatin domains determine function in the genome.
Tom Misteli, Elizabeth H. Finn
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Chromatin Architectures and Hox Gene Collinearity
2013Ever since the observation that collinearity, that is, the sequential activity of Hox genes based on their relative positions within their gene clusters, is conserved throughout most of the animal kingdom, the question has been raised as to what are the underlying molecular mechanisms.
Noordermeer, D. and Duboule, D.
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TCP Genes and the Orchestration of Plant Architecture
Tropical Plant Biology, 2020Several studies involving the TCP family have been carried out in the last two decades since the first members were discovered and the family was defined. The domain that names the family was well characterized and we know that the protein is a transcription factor that forms a non-canonical bHLH type structure capable of binding to the DNA molecule ...
Scott Carrara, Marcelo Carnier Dornelas
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Stripe forming architecture of the gap gene system
Developmental Genetics, 1998In this report, we show that gap genes encode exactly one set of pair-rule stripes, which occur in the native even-skipped position. The core of this work is a detailed analysis that shows how this conclusion follows from the arrangement of gap domains in the embryo.
David H. Sharp +3 more
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Performance Modeling of the Blue Gene Architecture
IEEE John Vincent Atanasoff 2006 International Symposium on Modern Computing (JVA'06), 2006In this work we analyze the performance of the largest installation of the Blue Gene/L architecture. This currently has the highest peak performance of any supercomputer. The performance characteristics of this machine are considered that gives rise to achievable application performance.
D.J. Kerbyson, A. Hoisie
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Roles of cohesin in chromosome architecture and gene expression
Seminars in Cell & Developmental Biology, 2019Cohesin-mediated chromatin organization plays an important role in formation and stabilization of chromosome architecture and gene regulation. Mechanisms by which cohesin shapes chromosome and regulates gene expression remain unclear. The present article overviews biological characters and functions of cohesin and core subunits and explores roles of ...
Xiangdong Wang, Zhenhua Zhu
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Archaeal promoter architecture and mechanism of gene activation
Biochemical Society Transactions, 2011Sulfolobus solfataricus and Sulfolobus islandicus contain several genes exhibiting D-arabinose-inducible expression and these systems are ideal for studying mechanisms of archaeal gene expression. At sequence level, only two highly conserved cis elements are present on the promoters: a regulatory element named ara box directing arabinose-inducible ...
Nan Peng +4 more
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