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Nonviral Gene Delivery with Dendritic Self-Assembling Architectures

Nanomedicine, 2014
In this review, we outline the concept and applicability of self-assembling dendrimers for gene-delivery applications. Low-molecular-weight, well-defined cationic dendritic arrays which have been modified with hydrophobic domains can form self-organized multivalent systems that have significant advantages over nonassembling, high-molecular-weight ...
Ariane, Tschiche   +2 more
openaire   +2 more sources

Nuclear architecture underlying gene expression in Trypanosoma brucei

Trends in Microbiology, 2007
The influence of nuclear architecture on the regulation of developmental gene expression has recently become evident in many organisms ranging from yeast to humans. During interphase, chromosomes and nuclear structures are in constant motion; therefore, correct temporal association is needed to meet the requirements of gene expression.
Miguel, Navarro   +2 more
openaire   +2 more sources

Stripe forming architecture of the gap gene system

Developmental Genetics, 1998
In this report, we show that gap genes encode exactly one set of pair-rule stripes, which occur in the native even-skipped position. The core of this work is a detailed analysis that shows how this conclusion follows from the arrangement of gap domains in the embryo.
J, Reinitz   +3 more
openaire   +2 more sources

Archaeal promoter architecture and mechanism of gene activation

Biochemical Society Transactions, 2011
Sulfolobus solfataricus and Sulfolobus islandicus contain several genes exhibiting D-arabinose-inducible expression and these systems are ideal for studying mechanisms of archaeal gene expression. At sequence level, only two highly conserved cis elements are present on the promoters: a regulatory element named ara box directing arabinose-inducible ...
Peng, Nan   +3 more
openaire   +3 more sources

Genes and networks regulating root anatomy and architecture

New Phytologist, 2015
SummaryThe root is an excellent model for studying developmental processes that underlie plant anatomy and architecture. Its modular structure, the lack of cell movement and relative accessibility to microscopic visualization facilitate research in a number of areas of plant biology.
Guy, Wachsman   +2 more
openaire   +2 more sources

Tandem Riboswitch Architectures Exhibit Complex Gene Control Functions

Science, 2006
Riboswitches are structured RNAs typically located in the 5′ untranslated regions of bacterial mRNAs that bind metabolites and control gene expression. Most riboswitches sense one metabolite and function as simple genetic switches. However, we found that the 5′ region of the Bacillus clausii metE
Narasimhan, Sudarsan   +6 more
openaire   +2 more sources

Establishing the Architecture of Plant Gene Regulatory Networks

2016
Gene regulatory grids (GRGs) encompass the space of all the possible transcription factor (TF)-target gene interactions that regulate gene expression, with gene regulatory networks (GRNs) representing a temporal and spatial manifestation of a portion of the GRG, essential for the specification of gene expression.
F, Yang   +4 more
openaire   +2 more sources

Cancer epigenetics in clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Veronica Davalos, Manel Esteller
exaly  

Variation in animal architecture: Genes, environment, and culture

Learning & Behavior
A new study investigates how stingless bee colonies inherit one of two architecturally distinct types of comb and proposes the primary mechanism of inheritance as stigmergy: among-individual coordination in comb building informed by environmental cues (i.e., social artefacts).
openaire   +2 more sources

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