Results 41 to 50 of about 754,180 (340)
Robust regulatory architecture of pan-neuronal gene expression [PDF]
Current Biology, 2021 ABSTRACTPan-neuronally expressed genes, such as genes involved in the synaptic vesicle release cycle or in neuropeptide maturation, are critical for proper function of all neurons, but the transcriptional control mechanisms that direct such genes to all neurons of a nervous system remain poorly understood.
Eduardo Leyva-Díaz, Oliver Hobert
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Food for thought: how nutrients regulate root system architecture [PDF]
, 2017 The spatial arrangement of the plant root system (root system architecture, RSA) is very sensitive to edaphic and endogenous signals that report on the nutrient status of soil and plant.
Amtmann, Anna, Shahzad, Zaigham
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Corruption of the intra-gene DNA methylation architecture is a hallmark of cancer. [PDF]
PLoS ONE, 2013 Epigenetic processes--including DNA methylation--are increasingly seen as having a fundamental role in chronic diseases like cancer. It is well known that methylation levels at particular genes or loci differ between normal and diseased tissue.
Thomas E Bartlett +5 more
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BreakTrans: uncovering the genomic architecture of gene fusions [PDF]
Genome Biology, 2013 AbstractProducing gene fusions through genomic structural rearrangements is a major mechanism for tumor evolution. Therefore, accurately detecting gene fusions and the originating rearrangements is of great importance for personalized cancer diagnosis and targeted therapy.
Chen, Ken +14 more
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SMC complexes link gene expression and genome architecture [PDF]
Current Opinion in Genetics & Development, 2014 The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture.
Dowen, Jill M., Young, Richard A.
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Theoretical principles of transcription factor traffic on folded chromatin
Nature Communications, 2018 How transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the ...
Ruggero Cortini, Guillaume J. Filion
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Turkish Journal of Agriculture: Food Science and Technology, 2018 The traditional fermented food consumption has become very popular because of the increasing public concern about food additives. Lactic Acid Bacteria (LAB) species have traditionally been used as starter cultures in the production of fermented food. LAB
Yekta Gezginç +3 more
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Multi-level remodelling of chromatin underlying activation of human T cells
Scientific Reports, 2021 Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage development but less so in response to cell perturbation.
Naiara G. Bediaga +10 more
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Insulators: linking genome architecture to gene regulation [PDF]
F1000 Biology Reports, 2009 Insulator elements have long been associated with a proposed domain boundary function, ensuring appropriate associations between regulatory elements and transcription units through the physical organisation of the genome into looped domains. Recent experiments in Drosophila have, however, highlighted a more direct involvement of insulators in ...
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Dissecting the regulatory architecture of gene expression QTLs [PDF]
Genome Biology, 2012 Abstract Background Expression quantitative trait loci (eQTLs) are likely to play an important role in the genetics of complex traits; however, their functional basis remains poorly understood.
Gaffney, Daniel J +8 more
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