Results 51 to 60 of about 322,007 (305)

Gene expression homeostasis and chromosome architecture [PDF]

BioArchitecture, 2014
In rapidly growing populations of bacterial cells, including those of the model organism Escherichia coli, genes essential for growth--such as those involved in protein synthesis--are expressed at high levels; this is in contrast to many horizontally-acquired genes, which are maintained at low transcriptional levels. (1) This balance in gene expression
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Enhancer Pleiotropy, Gene Expression, and the Architecture of Human Enhancer–Gene Interactions [PDF]

Molecular Biology and Evolution, 2021
AbstractEnhancers are often studied as noncoding regulatory elements that modulate the precise spatiotemporal expression of genes in a highly tissue-specific manner. This paradigm has been challenged by recent evidence of individual enhancers acting in multiple tissues or developmental contexts.
Devika Singh, Soojin V Yi
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Multi-level remodelling of chromatin underlying activation of human T cells

Scientific Reports, 2021
Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage development but less so in response to cell perturbation.
Naiara G. Bediaga, Hannah D. Coughlan, Timothy M. Johanson, Alexandra L. Garnham, Gaetano Naselli, Jan Schröder, Liam G. Fearnley, Esther Bandala-Sanchez, Rhys S. Allan, Gordon K. Smyth, Leonard C. Harrison   +10 more
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The Genetic Architecture of Gene Expression in Peripheral Blood [PDF]

The American Journal of Human Genetics, 2017
We analyzed the mRNA levels for 36,778 transcript expression traits (probes) from 2,765 individuals to comprehensively investigate the genetic architecture and degree of missing heritability for gene expression in peripheral blood. We identified 11,204 cis and 3,791 trans independent expression quantitative trait loci (eQTL) by using linear mixed ...
Lloyd-Jones, Luke R., Holloway, Alexander, McRae, Allan, Yang, Jian, Small, Kerrin, Zhao, Jing, Zeng, Biao, Bakshi, Andrew, Metspalu, Andres, Dermitzakis, Manolis, Gibson, Greg, Spector, Tim, Montgomery, Grant, Esko, Tonu, Visscher, Peter M., Powell, Joseph E.   +15 more
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Comparative 3D genome architecture in vertebrates

BMC Biology, 2022
Background The three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences the regulation of essential nuclear processes at the basis of gene expression, such as gene transcription.
Diyan Li, Mengnan He, Qianzi Tang, Shilin Tian, Jiaman Zhang, Yan Li, Danyang Wang, Long Jin, Chunyou Ning, Wei Zhu, Silu Hu, Keren Long, Jideng Ma, Jing Liu, Zhihua Zhang, Mingzhou Li   +15 more
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Architecture and dynamics of the jasmonic acid gene regulatory network [PDF]

The Plant Cell, 2016
ABSTRACTThe phytohormone jasmonic acid (JA) is a critical regulator of plant growth and defense. To significantly advance our understanding of the architecture and dynamics of the JA gene regulatory network, we performed high-resolution RNA-Seq time series analyses of methyl JA-treatedArabidopsis thaliana. Computational analysis unraveled in detail the
Marcel C. Van Verk, Aleksey Jironkin, Anja J.H. Van Dijken, Ivo Van der Nagel, Katherine J. Denby, Katherine J. Denby, Robert C. Schuurink, Richard Hickman, Irene A. Vos, Merel Steenbergen, Marciel Pereira Mendes, Gert Jan Wesselink, Adam Talbot, Adam Talbot, Michel de Vries, Corné M. J. Pieterse, Saskia C. M. Van Wees, Lotte Caarls, Johanna Rhodes   +18 more
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Enhancers dysfunction in the 3D genome of cancer cells

Frontiers in Cell and Developmental Biology, 2023
Eukaryotic genomes are spatially organized inside the cell nucleus, forming a threedimensional (3D) architecture that allows for spatial separation of nuclear processes and for controlled expression of genes required for cell identity specification and ...
Giulia Della Chiara, Carlos Jiménez, Mohit Virdi, Nicola Crosetto, Nicola Crosetto, Nicola Crosetto, Magda Bienko, Magda Bienko, Magda Bienko   +8 more
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Architecture, Chromatin and Gene Organization of Toxoplasma gondii Subtelomeres

Epigenomes, 2022
Subtelomeres (ST) are chromosome regions that separate telomeres from euchromatin and play relevant roles in various biological processes of the cell. While their functions are conserved, ST structure and genetic compositions are unique to each species ...
Susana M. Contreras, Romina T. Zambrano Siri, Elías M. Rivera, Constanza Cristaldi, Laura Kamenetzky, Kami Kim, Marina Clemente, Josefina Ocampo, Laura Vanagas, Sergio O. Angel   +9 more
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Genetic architecture of gene expression traits across diverse populations. [PDF]

PLoS Genetics, 2018
For many complex traits, gene regulation is likely to play a crucial mechanistic role. How the genetic architectures of complex traits vary between populations and subsequent effects on genetic prediction are not well understood, in part due to the ...
Lauren S Mogil, Angela Andaleon, Alexa Badalamenti, Scott P Dickinson, Xiuqing Guo, Jerome I Rotter, W Craig Johnson, Hae Kyung Im, Yongmei Liu, Heather E Wheeler   +9 more
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The Molecular Architecture of Plant Genes and Their Regulation

, 1989
Publisher Summary Plant gene expression is a highly regulated activity that is dependant upon a multitude of factors. One element of the regulation of gene expression is the primary structure of the gene itself. Primary structure, composed of the linear sequence elements of the DNA and RNA, may be responsible for the binding of various cellular ...
Keith O. Elliston, Joachim Messing
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