Results 51 to 60 of about 754,180 (340)
Comparative 3D genome architecture in vertebrates
BMC Biology, 2022 Background The three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences the regulation of essential nuclear processes at the basis of gene expression, such as gene transcription.
Diyan Li +15 more
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Architecture of a Yeast U6 RNA Gene Promoter [PDF]
Molecular and Cellular Biology, 1993 The promoters of vertebrate and yeast U6 small nuclear RNA genes are structurally dissimilar, although both are recognized by RNA polymerase III. Vertebrate U6 RNA genes have exclusively upstream promoters, while the U6 RNA gene from the yeast Saccharomyces cerevisiae (SNR6) has internal and downstream promoter elements that match the tRNA gene ...
J B, Eschenlauer +3 more
openaire +2 more sources
Genome-wide scanning versus candidate gene approach in the genetic architecture of common diseases. [PDF]
, 2007 In the Nature 7 June issue, researchers from the Welcome Trust Case Control Consortium (WTCCC) reported the findings of a large genome-wide association (GWA) study of 14,000 cases of common diseases and 3000 controls studies revealing the role of several
Carlos J. Pirola, Silvia Sookoian
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Enhancers dysfunction in the 3D genome of cancer cells
Frontiers in Cell and Developmental Biology, 2023 Eukaryotic genomes are spatially organized inside the cell nucleus, forming a threedimensional (3D) architecture that allows for spatial separation of nuclear processes and for controlled expression of genes required for cell identity specification and ...
Giulia Della Chiara +8 more
doaj +1 more source
The driver landscape of sporadic chordoma. [PDF]
, 2017 Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation. Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We reveal somatic duplications of the notochordal transcription factor brachyury (T)
Alexandrov, Ludmil B +31 more
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The Dynamic Architecture of Hox Gene Clusters
Science, 2011 Sequential activation of Hox genes correlates with a transition of negative to positive three-dimensional chromosome structure.
Noordermeer +10 more
openaire +3 more sources
Architecture, Chromatin and Gene Organization of Toxoplasma gondii Subtelomeres
Epigenomes, 2022 Subtelomeres (ST) are chromosome regions that separate telomeres from euchromatin and play relevant roles in various biological processes of the cell. While their functions are conserved, ST structure and genetic compositions are unique to each species ...
Susana M. Contreras +9 more
doaj +1 more source
Genetic architecture of gene expression traits across diverse populations. [PDF]
PLoS Genetics, 2018 For many complex traits, gene regulation is likely to play a crucial mechanistic role. How the genetic architectures of complex traits vary between populations and subsequent effects on genetic prediction are not well understood, in part due to the ...
Lauren S Mogil +9 more
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Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Analysis, Tracing, Characterization and Performance Modeling of Select ASCI Applications for BlueGene/L Using Parallel Discrete Event Simulation [PDF]
, 2003 Caltech's Jet Propulsion Laboratory (JPL) and Center for Advanced Computer Architecture (CACR) are conducting application and simulation analyses of Blue Gene/L[1] in order to establish a range of effectiveness of the architecture in performing important
Brodowicz, Maciej +4 more
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