Results 61 to 70 of about 322,007 (305)
The role of gene architecture in gene expression
EMBnet.journal, 2013 Recent global studies in several species have indicated that most intron removal is co-transcriptional, underscoring the potential for coupling between the transcription and splicing machineries as well as chromatin.Our work is conducted in mammalian tissue culture cells, zebrafish embryos, and budding and fission yeasts. This work will report on a new
openaire +2 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Promoter Architecture Dictates Variability in Gene Expression [PDF]
Biophysical Journal, 2014 Recent experimental studies have reported that cell-to-cell variability in gene expression is a universal function of mean gene expression levels, implying that knowledge of mean levels of gene expression alone is sufficient to determine the level of variability. This result seems at odds with the physical intuition underlying efforts in the literature
Jones, Daniel L. +2 more
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FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Chromatin architecture and gene expression in Escherichia coli.
Genome biology, 2004 Two recent genome-scale analyses underscore the importance of DNA topology and chromatin structure in regulating transcription in Escherichia coli.
Willenbrock, Hanni, Ussery, David
openaire +4 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Chromosome architecture constrains horizontal gene transfer in bacteria.
PLoS Genetics, 2018 Despite significant frequencies of lateral gene transfer between species, higher taxonomic groups of bacteria show ecological and phenotypic cohesion. This suggests that barriers prevent panmictic dissemination of genes via lateral gene transfer. We have
Heather L Hendrickson +3 more
doaj +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons
Genomics, Proteomics & Bioinformatics, 2023 The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture of chromatin. Morphine-induced aberrant gene networks of neurons have been extensively investigated; however, how morphine impacts the 3D genomic ...
Liang Wang +21 more
doaj +1 more source
FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley +1 more source