Results 81 to 90 of about 754,180 (340)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Mechanisms of enhancer-promoter communication and chromosomal architecture in mammals and Drosophila

Frontiers in Genetics, 2022
The spatial organization of chromosomes is involved in regulating the majority of intranuclear processes in higher eukaryotes, including gene expression. Drosophila was used as a model to discover many transcription factors whose homologs play a key role
Olga V. Kyrchanova, Oleg V. Bylino, Pavel G. Georgiev   +2 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Single-Cell Transcriptomics Reveal a Correlation between Genome Architecture and Gene Family Evolution in Ciliates

mBio, 2019
Ciliates, a eukaryotic clade that is over 1 billion years old, are defined by division of genome function between transcriptionally inactive germline micronuclei and functional somatic macronuclei.
Ying Yan, Xyrus X. Maurer-Alcalá, Rob Knight, Sergei L. Kosakovsky Pond, Laura A. Katz   +4 more
doaj   +1 more source

Feedbacks from the metabolic network to the genetic network reveal regulatory modules in E. coli and B. subtilis

, 2018
The genetic regulatory network (GRN) plays a key role in controlling the response of the cell to changes in the environment. Although the structure of GRNs has been the subject of many studies, their large scale structure in the light of feedbacks from ...
Jain, Sanjay, Kumar, Santhust, Mahajan, Saurabh   +2 more
core   +2 more sources

Effect of promoter architecture on the cell-to-cell variability in gene expression [PDF]

, 2010
According to recent experimental evidence, the architecture of a promoter, defined as the number, strength and regulatory role of the operators that control the promoter, plays a major role in determining the level of cell-to-cell variability in gene ...
A Bar-Even, A Gansen, A Raj, A Raj, A Sanchez, A Singh, A Warmflash, AC Babic, AD Cameron, Alvaro Sanchez, B Muller-Hill, BS Burz, C Zurla, CD Cox, CD Cox, D Kennell, D Müller, D Nevozhay, D Zenklusen, Daniel Jones, DF Browning, DR Rigney, DT Gillespie, DW Austin, E Segal, EM Ozbudak, F Vanzi, F Vanzi, FMV Rossi, G Li, G Tkacik, H Boeger, H Maamar, HD Kim, HD Kim, Hernan G. Garcia, I Golding, IB Dodd, J Elf, J Gertz, J Müller, J Ou, J Paulsson, J Paulsson, J Peccoud, J Yu, Jané Kondev, JK Joung, JK Joung, JM Pedraza, JM Pedraza, JM Raser, JM Vilar, JM Vilar, JR Chubb, JS van Zon, K Gaston, KF Murphy, KS Koblan, L Bintu, L Bintu, L Cai, L Saiz, LS Weinberger, M Ackerman, M Dobrzynski, M Kaern, M Ptashne, M Shin, M Thattai, M Voliotis, MA Shea, MB Elowitz, MF Wernet, MJ Dunlop, N Maheshri, N Rosenfeld, NE Buchler, O Berg, OK Wong, PJ Choi, PJ Ingram, PJ Schlax, PS Gutierrez, PS Swain, R Losik, Rob Phillips, S Klumpp, S Semsey, SB Straney, SE Halford, T Höfer, T Kuhlman, T Raveh-Sadka, TB Kepler, TL To, TP Malan, TS Karpova, U Moran, V Shahrezaei, WJ Blake, WJ Blake, Wyeth W. Wasserman, Y Taniguchi, Y Wang   +104 more
core   +5 more sources

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease [PDF]

, 2023
Andrés Tapia del Fierro, Bianca den Hamer, Natalia Benetti, Natasha Jansz, Kelan Chen, Tamara Beck, Hannah Vanyai, Alexandra D. Gurzau, Lucia Daxinger, Shifeng Xue, Thanh Thao Nguyen Ly, Iromi Wanigasuriya, Megan Iminitoff, Kelsey Breslin, Harald Oey, Yvonne D. Krom, Dinja van der Hoorn, Linde F. Bouwman, Timothy M. Johanson, Matthew E. Ritchie, Quentin Gouil, Bruno Reversade, Fabrice Prin, Timothy J. Mohun, Silvère M. van der Maarel, Edwina McGlinn, James M. Murphy, Andrew Keniry, Jessica C. de Greef, Marnie E. Blewitt   +29 more
openalex   +1 more source

The constrained architecture of mammalian Hox gene clusters [PDF]

Proceedings of the National Academy of Sciences, 2019
In many animal species with a bilateral symmetry, Hox genes are clustered either at one or at several genomic loci. This organization has a functional relevance, as the transcriptional control applied to each gene depends upon its relative position within the gene cluster. It was previously noted that vertebrate
Darbellay, Fabrice, Bochaton, Célia, Lopez-Delisle, Lucille, Mascrez, Bénédicte, Tschopp, Patrick, Delpretti, Saskia, Zakany, Jozsef, Duboule, Denis   +7 more
openaire   +5 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The role of the plant microbiome for forestry, agriculture and urban greenspace in times of environmental change

Microbial Biotechnology
This Lilliput article provides a literature overview on ecological effects of the plant microbiome with a focus on practical application in forestry, agriculture and urban greenspace under the spectre of climate change.
Felix Brüssow, Friederike Bruessow, Harald Brüssow   +2 more
doaj   +1 more source