Results 211 to 220 of about 2,576,180 (238)

Comprehensive Molecular Characterization of Extensively Drug-Resistant <i>Acinetobacter baumannii</i> Isolated from Intensive Care Unit Patients: Carbapenemase Genes, Plasmid-Mediated Resistance Determinants, and PFGE-Based Clonal Analysis. [PDF]

Pharmaceuticals (Basel)
Öztürk C.
europepmc   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Genomic Context and Insert Orientation in the Regulation of Transgene Expression in Adenoviral Vectors. [PDF]

Int J Mol Sci
Muravyeva A, Smirnikhina S.
europepmc   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Recombinant Expression of Chitinase CtChi70 in Komagataella phaffii for Sustainable N, N'-Diacetyl-Chitobiose Production From Shrimp Shells. [PDF]

Biotechnol J
Chu Q, Lin Y, Zhang S, Zou C, Wang C, Soteyome T, Xu Z, Ye Y.   +7 more
europepmc   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, EarlyView.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

<i>In Silico</i> Design of <i>phaCAB</i> Expression Constructs for Cellulolytic Hosts Toward Hemp Hurd Valorisation and Polyhydroxybutyrate Biosynthesis. [PDF]

Molecules
Myeni ZR, Gumede S, Ntombela N, Dziike F, Deenadayalu N.   +4 more
europepmc   +1 more source

U2AF1 modulates alternative exon selection and guards zygotic splicing activation in mouse preimplantation embryogenesis. [PDF]

Cell Mol Life Sci
Jiang ZY, Wu X, Jia MY, Chen L, Liu YQ, Fan HY, Zhang YL.   +6 more
europepmc   +1 more source

Expanding the Genetic Toolkit of Pichia kudriavzevii E1 for Enhanced Mycoprotein Production. [PDF]

Microb Biotechnol
Wang Y, Gao S, Wu C, Guo L, Han P, Wang L, Ruchała J, Yu B.   +7 more
europepmc   +1 more source