Results 111 to 120 of about 3,039,728 (253)

Molecular genetical analysis of the nitrate gene cluster of Aspergillus nidulans [PDF]

, 2015
Putative DNA clones harbouring the nitrate gene cluster of Aspergillus nidulans was used in a number of transformation experiments to positively identify the clones.
Greaves, Philip Andrew
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Research Progress of Laccase in Edible and Medicinal Fungi

Journal of Fungi
This paper systematically reviews the research progress on the physiological functions, gene cloning, classification basis, and expression regulation mechanisms of laccase in edible and medicinal fungi.
Yanshu Zhao, Xiaojia Zhang, Yuxin Jiang, Shuyuan Song, Chuang Han, Xiaodong Dai   +5 more
doaj   +1 more source

Gene cloning, expression, and characterization of two endo-xylanases from Bacillus velezensis and Streptomyces rochei, and their application in xylooligosaccharide production. [PDF]

Front Microbiol, 2023
Zhang J, Qin Y, Wang Q, Liu S, Zhou J, He B, Liang X, Xian L, Wu J.   +8 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Cloning of, and studies on, genes coding for subtilisins Carlsberg and BPN' [PDF]

The alkaline serine proteases (subtilisins) secreted by the Bacillus spp. can be categorized into two groups on the basis of immunological cross-reactions. A gene coding for the Carlsberg type was cloned from B.
Jacobs, Myra Freda
core  

RFLP pattern of the -gene-like -genes; cloning and hybridization of the sequences with high degree of homology to the fourth exon of the -gene

, 2011
Copyright information:Taken from "Transgenerational changes in the genome stability and methylation in pathogen-infected plants"Nucleic Acids Research 2007;35(5):1714-1725.Published online 20 Feb 2007PMCID:PMC1865051.© 2007 The Author(s).
Youli Yao (28474), Igor Pogribny (28475), Palak Kathiria (28472), Igor Kovalchuk (28476), Alexander Boyko (28471), Franz J. Zemp (28473)   +5 more
core   +1 more source

ADH Gene Cloning and Identification of Flooding-Responsive Genes in Taxodium distichum (L.) Rich. [PDF]

Plants (Basel), 2023
Zhang R, Xuan L, Ni L, Yang Y, Zhang Y, Wang Z, Yin Y, Hua J.   +7 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source