Results 101 to 110 of about 3,039,728 (253)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Cloning and Expression of Pseudomonas aeruginosa AlkB Gene in E. coli
, 2020 Pre identified hydrocarbons degrading bacteria were used in this study, specific primer was conducted to amplification of AlkB gene, approximately 1206bp band size of this gene for Pseudomonas aeruginosa was detected and proofed by sequence and ...
Rasha M. Othman, Fadhil N. Al-Kanany
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Journal of Genetic Engineering and BiotechnologyThe post-genome sequencing era faces the challenge of understanding gene functions. While model organisms and mutagenesis screens are helpful, they can be labor-intensive.
Maytham. A. Dragh +2 more
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Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
The human SOX18 gene: cDNA cloning and high resolution mapping
, 2000 SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY and these genes play key roles during animal development. We report here cloning and characterisation of the human SOX18 gene.
Stevanović, Milena +2 more
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Expression of leoA gene of Helicobacter pylori in CHO animal cells by RT-PCR method
مجله دانشگاه علوم پزشکی گرگان, 2017 Background and Objective: Helicobacter pylori infection is one of the most common chronic bacterial infections all over the world, particularly in the developing countries. LeoA gene plays an important role in pathogenesis, and the main role of this gene
Naghmeh Mirabolghasemi, Abbas Doosti
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Animal and Human Cloning Data. National Academy of Sciences Forum (2001 August 7) (Part 5)
, 2001 "Dr. Wilmut discussed the applicabilty of animal cloning data to human cloning. He was the scientist who cloned the sheep "Dolly" in Scotland. Dr. Van Steirteghem reviewed assisted reproductive technology in humans. Dr.
Producer: National Cable Satellite Corporation
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