Results 101 to 110 of about 497,526 (307)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Cloning of Stb6 - the first gene conferring race-specific resistance against the Septoria tritici blotch disease

, 2016
Cloning of Stb6 – the first gene conferring race-specific resistance against the Septoria tritici blotch disease. 9.
Kanyuka, K., Phillips, A. L., Cambon, Florence, Uauy, C., Lee, W-S., Saintenac, Cyrille, Hammond-Kosack, K. E., Langin, T., Kanyuka, Kostya, Lee, W.S., Langin, Thierry, Saintenac, C., Phillips, Andy L., Cambon, F., King, R., Hammond-Kosack, Kim, Uauy, Cristobal   +16 more
core  

Improved Screening of cDNAs Generated by mRNA Differential Display Enables the Selection of True Positives and the Isolation of Weakly Expressed Messages [PDF]

, 1997
The high percentage of false positives generated by differential display (as high as 85%) has previously limited the potential of the method. This report describes an efficient methodology that enables false positives to be discarded prior to cloning ...
Latché, Alain, Pech, Jean-Claude, Zegzouti, Hicham, Jones, Brian, Marty, Christel, Bouquin, Thomas, Bouzayen, Mondher   +6 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Rapid Gene Cloning in Wheat [PDF]

, 2019
The identification of wheat and barley genes controlling important agronomic traits using positional cloning has traditionally been a challenging and time-consuming procedure.
M. Asyraf Md. Hatta, Md. Hatta, M. Asyraf, Brande B.H. Wulff, Burkhard Steuernagel, Steuernagel, Burkhard, Wulff, Brande B. H.   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]

, 2009
OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali, Mathieu, Florence, Liboz, Thierry, Bacha, Nafees, Lebrihi, Ahmed   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cloning and sequence analysis of the eburicol 14alpha-demethylase encoding gene (CYP51 ) from the Japanese pear scab fungus Venturia nashicola

, 2002
The slow growth of many lamentous fungi in vitro prevents rapid isolation of large quantities of genomic DNA, thereby hampering molecular studies.
Hollomon, D. W., Ishii, H., J. A. Butters, D. W. Hollomon, H. Ishii, Butters, J. A., Cools, H. J., H. J. Cools   +7 more
core   +1 more source

Gene Structure, cDNA Sequence, and mRNA Distribution [PDF]

, 1994
The rat HNF-3 (hepatocyte nuclear factor 3) gene family encodes three transcription factors known to be important in the regulation of gene expression in liver and lung.
Schütz, Günther, Kaestner, Klaus H., Hiemisch, Holger, Luckow, Bruno   +3 more
core   +1 more source