Results 81 to 90 of about 497,526 (307)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

SnTox3 acts in effector triggered susceptibility to induce disease on wheat carrying the Snn3 gene

, 2009
The necrotrophic fungus Stagonospora nodorum produces multiple proteinaceous host-selective toxins (HSTs) which act in effector triggered susceptibility.
McDonald, B., McDonald Megan C., Nunez, A., Faris Justin D., Liu, Z., Zhaohui Liu, Friesen Timothy L., Tan, Kar-Chun, Oliver, R.P., Faris, Justin D., Kar-Chun Tan, Oliver, Richard P., Rasmussen, Jack B., Lu Shunwen, Solomon Peter S., Richard P Oliver, Friesen, T., Tan, K.C., Megan C McDonald, McDonald, M., Oliver Richard P., Bruce A McDonald, Friesen, T.L., Jack B Rasmussen, McDonald, Megan C., McDonald, Megan C.; id_orcid, Faris, J.D., Peter S Solomon, Liu Zhaohui, Nunez, Alberto, McDonald, Bruce A., Rasmussen, J., Rasmussen Jack B., Friesen, Timothy L., Faris, J., McDonald Bruce A., Oliver, Richard, Liu, Zhaohui, McDonald, B.A., Rasmussen, J.B., Nunez Alberto, Solomon, Peter S., Tan Kar-Chun, Timothy L Friesen, Solomon, P., McDonald, M.C., Lu, S., Shunwen Lu, Justin D Faris, Alberto Nunez, Lu, Shunwen, Solomon, P.S.   +51 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The human SOX18 gene: cDNA cloning and high resolution mapping

, 2000
SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY and these genes play key roles during animal development. We report here cloning and characterisation of the human SOX18 gene.
Stevanović, Milena, Stanojcić, S, Stanojčić, Slavica   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mutagenesis and Gene Cloning in Schizosaccharomyces pombe Using Nonhomologous Plasmid Integration and Rescue

BioTechniques, 2000
Genes are commonly cloned in yeasts and bacteria by plasmid complementation, where the introduction of the gene of interest into a host strain carrying a recessive mutation in that gene suppresses the host’s mutant phenotype.
Charles S. Hoffman, Robert Welton
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

RFLP pattern of the -gene-like -genes; cloning and hybridization of the sequences with high degree of homology to the fourth exon of the -gene

, 2011
Copyright information:Taken from "Transgenerational changes in the genome stability and methylation in pathogen-infected plants"Nucleic Acids Research 2007;35(5):1714-1725.Published online 20 Feb 2007PMCID:PMC1865051.© 2007 The Author(s).
Youli Yao (28474), Igor Pogribny (28475), Palak Kathiria (28472), Igor Kovalchuk (28476), Alexander Boyko (28471), Franz J. Zemp (28473)   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cloning of intronic sequence within DsRed2 increased the number of cells expressing red fluorescent protein

Biomedical Papers, 2017
Aim: Cloning of artificial intronic sequence within the open reading frame (ORF) of DsRed2 gene. Method: Splice prediction software was used to analyze DsRed2 sequence to find an ideal site for cloning artificial intronic sequence.
Rishikaysh V. Pisal, Hana Hrebikova, Jana Chvatalova, Tomas Soukup, Stanislav Filip, Jaroslav Mokry   +5 more
doaj   +1 more source