Results 1 to 10 of about 8,793,913 (366)

The Sporisorium reilianum Effector Vag2 Promotes Head Smut Disease via Suppression of Plant Defense Responses

Journal of Fungi, 2022
Genome comparison between the maize pathogens Ustilago maydis and Sporisorium reilianum revealed a large diversity region (19-1) containing nearly 30 effector gene candidates, whose deletion severely hampers virulence of both fungi.
Yulei Zhao, Nisha Agrawal, Hassan Ghareeb, Mohammad Tanbir Habib, Sascha Dickmeis, Jens Schwachtje, Tim E. Iven, Joachim Kopka, Ivo Feussner, Jan Schirawski   +9 more
doaj   +1 more source

Transcription mediated insulation and interference direct gene cluster expression switches

eLife, 2014
In yeast, many tandemly arranged genes show peak expression in different phases of the metabolic cycle (YMC) or in different carbon sources, indicative of regulation by a bi-modal switch, but it is not clear how these switches are controlled.
Tania Nguyen, Harry Fischl, Françoise S Howe, Ronja Woloszczuk, Ana Serra Barros, Zhenyu Xu, David Brown, Struan C Murray, Simon Haenni, James M Halstead, Leigh O'Connor, Gergana Shipkovenska, Lars M Steinmetz, Jane Mellor   +13 more
doaj   +1 more source

Characterization of the Largest Effector Gene Cluster of Ustilago maydis

PLoS Pathogens, 2014
In the genome of the biotrophic plant pathogen Ustilago maydis, many of the genes coding for secreted protein effectors modulating virulence are arranged in gene clusters. The vast majority of these genes encode novel proteins whose expression is coupled
Thomas Brefort, Shigeyuki Tanaka, Nina Neidig, G. Doehlemann, Volker Vincon, R. Kahmann   +5 more
semanticscholar   +1 more source

Lower Funneling Pathways in Scedosporium Species

Frontiers in Microbiology, 2021
Lignin, a natural polyaromatic macromolecule, represents an essential component of the lignocellulose biomass. Due to its complexity, the natural degradation of this molecule by microorganisms still remains largely misunderstood.
Wilfried Poirier, Kevin Ravenel, Jean-Philippe Bouchara, Sandrine Giraud   +3 more
doaj   +1 more source

Identification and Characterization of Mycemycin Biosynthetic Gene Clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235

Marine Drugs, 2018
Mycemycins A–E are new members of the dibenzoxazepinone (DBP) family, derived from the gntR gene-disrupted deep sea strain Streptomyces olivaceus FXJ8.012Δ1741 and the soil strain Streptomyces sp. FXJ1.235.
Fangying Song, Ning Liu, Minghao Liu, Yihua Chen, Ying Huang   +4 more
doaj   +1 more source

Activation and Characterization of a Cryptic Polycyclic Tetramate Macrolactam Biosynthetic Gene Cluster

Nature Communications, 2013
Polycyclic tetramate macrolactams (PTMs) are a widely distributed class of natural products with important biological activities. However, many of these PTMs have not been characterized.
Yunzi Luo, Hua Huang, Jing Liang, M. Wang, Lu Lu, Zengyi Shao, R. Cobb, Huimin Zhao   +7 more
semanticscholar   +1 more source

Gene-Function-Based Clusters Explore Intricate Networks of Gene Expression of Circulating Tumor Cells in Patients with Colorectal Cancer

Biomedicines, 2023
Colorectal cancer (CRC) is a complex disease characterized by dynamically deregulated gene expression and crosstalk between signaling pathways. In this study, a new approach based on gene-function-based clusters was introduced to explore the CRC ...
Chi-Shuan Huang, Harn-Jing Terng, Yi-Ting Hwang   +2 more
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The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

PLoS Genetics, 2013
The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant drug cyclosporin. The draft genome of T.
Kathryn E. Bushley, R. Raja, P. Jaiswal, Jason S. Cumbie, Mariko Nonogaki, Alex Boyd, C. A. Owensby, B. Knaus, J. Elser, Daniel Miller, Y. Di, K. McPhail, J. Spatafora   +12 more
semanticscholar   +1 more source

Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast

Molecular biology and evolution, 2013
The genes encoding many biomolecular systems and pathways are genomically organized in operons or gene clusters. With MultiGeneBlast, we provide a user-friendly and effective tool to perform homology searches with operons or gene clusters as basic units,
M. Medema, E. Takano, R. Breitling
semanticscholar   +1 more source

Genomic and Metabolomic Analyses of Natural Products in Nodularia spumigena Isolated from a Shrimp Culture Pond

Toxins, 2020
The bloom-forming cyanobacterium Nodularia spumigena CENA596 encodes the biosynthetic gene clusters (BGCs) of the known natural products nodularins, spumigins, anabaenopeptins/namalides, aeruginosins, mycosporin-like amino acids, and scytonemin, along ...
Rafael Vicentini Popin, Endrews Delbaje, Vinicius Augusto Carvalho de Abreu, Janaina Rigonato, Felipe Augusto Dörr, Ernani Pinto, Kaarina Sivonen, Marli Fatima Fiore   +7 more
doaj   +1 more source