Results 1 to 10 of about 9,738,594 (396)

Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]

, 2013
Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Best, AA, Broussard, GW, Connerly, PL, Conway, JF, Dedrick, RM, Hatfull, GF, Hendrix, RW, Jacobs-Sera, D, Kremer, TA, Offner, S, Ogiefo, AH, Pizzorno, MC, Pope, WH, Rockenbach, K, Russell, DA, Stowe, EL, Stukey, J, Thibault, SA   +17 more
core   +30 more sources

A rapid combinatorial assembly method for gene cluster characterisation illuminates glidobactin biosynthesis. [PDF]

Synth Syst Biotechnol
Calcott MJ, Kröger J, Ackerley DF.
europepmc   +2 more sources

CAGECAT: The CompArative GEne Cluster Analysis Toolbox for rapid search and visualisation of homologous gene clusters

bioRxiv, 2023
Background Co-localized sets of genes that encode specialized functions are common across microbial genomes and occur in genomes of larger eukaryotes as well.
Matthias van den Belt, C. Gilchrist, Thomas J. Booth, Y. Chooi, M. Medema, Mohammad Alanjary   +5 more
semanticscholar   +1 more source

Synergistic Roles of Curcumin in Sensitising the Cisplatin Effect on a Cancer Stem Cell-Like Population Derived from Non-Small Cell Lung Cancer Cell Lines

Molecules, 2021
Cancer stem cells (CSCs) represent a small subpopulation within a tumour. These cells possess stem cell-like properties but also initiate resistance to cytotoxic agents, which contributes to cancer relapse. Natural compounds such as curcumin that contain
Nazilah Abdul Satar, Mohd Nazri Ismail, Badrul Hisham Yahaya   +2 more
doaj   +1 more source

Molecular Components of Nitrogen Fixation Gene Cluster and Associated Enzymatic Activities of Non-Heterocystous Thermophilic Cyanobacterium Thermoleptolyngbya sp.

Life, 2021
Thermoleptolyngbya is a genus of non-heterocystous cyanobacteria that are typical inhabitants of hot spring microbial mats. These filamentous cyanobacteria are capable of nitrogen fixation. In this study, we examined the genome sequences of five publicly
Meijin Li, Lei Cheng, Jie Tang, Maurycy Daroch   +3 more
doaj   +1 more source

Secondary Metabolism Gene Clusters Exhibit Increasingly Dynamic and Differential Expression during Asexual Growth, Conidiation, and Sexual Development in Neurospora crassa

mSystems, 2022
Secondary metabolite clusters (SMCs) encode the machinery for fungal toxin production. However, understanding their function and analyzing their products requires investigation of the developmental and environmental conditions in which they are expressed.
Zheng Wang, Francesc Lopez-Giraldez, Jason Slot, Oded Yarden, Frances Trail, Jeffrey P. Townsend   +5 more
doaj   +1 more source

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis. [PDF]

Nat Commun
Hakim SE, Choudhary N, Malhotra K, Peng J, Bültemeier A, Arafa A, Friedhoff R, Bauer M, Eikenberg J, Witte CP, Herde M, Heretsch P, Pucker B, Franke J.   +13 more
europepmc   +2 more sources

clinker & clustermap.js: Automatic generation of gene cluster comparison figures

bioRxiv, 2020
Summary Genes involved in biological pathways are often collocalised in gene clusters, the comparison of which can give valuable insights into their function and evolutionary history.
C. Gilchrist, Y. Chooi
semanticscholar   +1 more source

antiSMASH 6.0: improving cluster detection and comparison capabilities

Nucleic Acids Res., 2021
Many microorganisms produce natural products that form the basis of antimicrobials, antivirals, and other drugs. Genome mining is routinely used to complement screening-based workflows to discover novel natural products.
K. Blin, S. Shaw, Alexander M. Kloosterman, Z. Charlop-Powers, G. P. Wezel, M. Medema, T. Weber   +6 more
semanticscholar   +1 more source

BiG-FAM: the biosynthetic gene cluster families database

Nucleic Acids Res., 2020
Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural product discovery by enabling the rapid investigation of secondary metabolic potential within microbial genome sequences.
S. Kautsar, K. Blin, S. Shaw, T. Weber, M. Medema   +4 more
semanticscholar   +1 more source