Results 131 to 140 of about 9,738,594 (396)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The Finding of a Group IIE Phospholipase A2 Gene in a Specified Segment of Protobothrops flavoviridis Genome and Its Possible Evolutionary Relationship to Group IIA Phospholipase A2 Genes

Toxins, 2014
The genes encoding group IIE phospholipase A2, abbreviated as IIE PLA2, and its 5' and 3' flanking regions of Crotalinae snakes such as Protobothrops flavoviridis, P. tokarensis, P. elegans, and Ovophis okinavensis, were found and sequenced.
Kazuaki Yamaguchi, Takahito Chijiwa, Naoki Ikeda, Hiroki Shibata, Yasuyuki Fukumaki, Naoko Oda-Ueda, Shosaku Hattori, Motonori Ohno   +7 more
doaj   +1 more source

Identification and Characterization of a Novel Diterpene Gene Cluster in Aspergillus nidulans

PLoS ONE, 2012
Fungal secondary metabolites are a rich source of medically useful compounds due to their pharmaceutical and toxic properties. Sequencing of fungal genomes has revealed numerous secondary metabolite gene clusters, yet products of many of these ...
Kirsi Bromann, M. Toivari, K. Viljanen, A. Vuoristo, L. Ruohonen, T. Nakari-Setälä   +5 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti

Frontiers in Microbiology, 2017
Penicillium roqueforti is a filamentous fungus involved in the ripening of several kinds of blue cheeses. In addition, this fungus produces several secondary metabolites, including the meroterpenoid compound andrastin A, a promising antitumoral compound.
Juan F. Rojas-Aedo, Carlos Gil-Durán, Abdiel Del-Cid, Natalia Valdés, Pamela Álamos, Inmaculada Vaca, Ramón O. García-Rico, Gloria Levicán, Mario Tello, Renato Chávez   +9 more
doaj   +1 more source

Clustering of gene expression profiles: creating initialization-independent clusterings by eliminating unstable genes

Journal of Integrative Bioinformatics, 2010
SummaryClustering is an important approach in the analysis of biological data, and often a first step to identify interesting patterns of coexpression in gene expression data. Because of the high complexity and diversity of gene expression data, many genes cannot be easily assigned to a cluster, but even if the dissimilarity of these genes with all ...
De Mulder Wim, Kuiper Martin, Boel René
openaire   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Mining public genomic databases for novel lanthipeptides: a case study on Bacillus amyloliquefaciens

Biotechnology & Biotechnological Equipment
The increasing prevalence of drug-resistant bacteria has prompted the search for alternative approaches to address bacterial infections. Lanthipeptides, which are small molecule peptides, are biosynthesized and post-translationally modified by ribosomes ...
Wenya Zhao, Yang Zhang, Xue Yang, Jianuo He, Yana Wang, Feiyan Zhang, Liping Zhang, Hongwei Liu   +7 more
doaj   +1 more source

Four basic symmetry types in the universal 7-cluster structure of 143 complete bacterial genomic sequences [PDF]

, 2004
Coding information is the main source of heterogeneity (non-randomness) in the sequences of bacterial genomes. This information can be naturally modeled by analysing cluster structures in the ``in-phase'' triplet distributions of relatively short genomic
Gorban, A.N., Popova, T.G., Zinovyev, A.Yu.   +2 more
core   +1 more source

Adaptive Evolution of the FADS Gene Cluster within Africa

PLoS ONE, 2012
Long chain polyunsaturated fatty acids (LC-PUFAs) are essential for brain structure, development, and function, and adequate dietary quantities of LC-PUFAs are thought to have been necessary for both brain expansion and the increase in brain complexity ...
R. Mathias, Wenqing Fu, J. Akey, H. Ainsworth, D. Torgerson, I. Ruczinski, S. Sergeant, K. Barnes, F. Chilton   +8 more
semanticscholar   +1 more source