Results 11 to 20 of about 8,793,913 (366)
Co-Regulated Genes and Gene Clusters [PDF]
Genes, 2021 There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with
Sergey V. Razin +3 more
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Supervised clustering of genes [PDF]
Genome Biology, 2002 We focus on microarray data where experiments monitor gene expression in different tissues and where each experiment is equipped with an additional response variable such as a cancer type. Although the number of measured genes is in the thousands, it is assumed that only a few marker components of gene subsets determine the type of a tissue.
Peter Bühlmann, Marcel Dettling
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Molecules, 2021 Cancer stem cells (CSCs) represent a small subpopulation within a tumour. These cells possess stem cell-like properties but also initiate resistance to cytotoxic agents, which contributes to cancer relapse. Natural compounds such as curcumin that contain
Nazilah Abdul Satar +2 more
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Life, 2021 Thermoleptolyngbya is a genus of non-heterocystous cyanobacteria that are typical inhabitants of hot spring microbial mats. These filamentous cyanobacteria are capable of nitrogen fixation. In this study, we examined the genome sequences of five publicly
Meijin Li +3 more
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mSystems, 2022 Secondary metabolite clusters (SMCs) encode the machinery for fungal toxin production. However, understanding their function and analyzing their products requires investigation of the developmental and environmental conditions in which they are expressed.
Zheng Wang +5 more
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Gene Cluster Statistics with Gene Families [PDF]
Molecular Biology and Evolution, 2009 Identifying genomic regions that descended from a common ancestor is important for understanding the function and evolution of genomes. In distantly related genomes, clusters of homologous gene pairs are evidence of candidate homologous regions. Demonstrating the statistical significance of such "gene clusters" is an essential component of comparative ...
Dannie Durand, Narayanan Raghupathy
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clinker & clustermap.js: Automatic generation of gene cluster comparison figures
bioRxiv, 2020 Summary Genes involved in biological pathways are often collocalised in gene clusters, the comparison of which can give valuable insights into their function and evolutionary history.
C. Gilchrist, Y. Chooi
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BiG-FAM: the biosynthetic gene cluster families database
Nucleic Acids Res., 2020 Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural product discovery by enabling the rapid investigation of secondary metabolic potential within microbial genome sequences.
S. Kautsar +4 more
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Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity
bioRxiv, 2020 Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways.
P. Fan +10 more
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Statistics for approximate gene clusters [PDF]
BMC Bioinformatics, 2013 Genes occurring co-localized in multiple genomes can be strong indicators for either functional constraints on the genome organization or remnant ancestral gene order. The computational detection of these patterns, which are usually referred to as gene clusters, has become increasingly sensitive over the past decade.
Jahn, Katharina +3 more
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