Results 11 to 20 of about 9,738,594 (396)

Co-Regulated Genes and Gene Clusters [PDF]

open access: yesGenes, 2021
There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with
Sergey V. Razin   +3 more
openaire   +2 more sources

Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme

open access: yesBeilstein Journal of Organic Chemistry, 2022
Fusicoccane-type terpenoids are a subgroup of diterpenoids featured with a unique 5-8-5 ring system. They are widely distributed in nature and possess a variety of biological activities.
Jia-Hua Huang   +9 more
doaj   +1 more source

Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity

open access: yesbioRxiv, 2020
Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways.
P. Fan   +10 more
semanticscholar   +1 more source

Supervised clustering of genes [PDF]

open access: yesGenome Biology, 2002
We focus on microarray data where experiments monitor gene expression in different tissues and where each experiment is equipped with an additional response variable such as a cancer type. Although the number of measured genes is in the thousands, it is assumed that only a few marker components of gene subsets determine the type of a tissue.
Marcel, Dettling, Peter, Bühlmann
openaire   +2 more sources

Gene Cluster Statistics with Gene Families [PDF]

open access: yesMolecular Biology and Evolution, 2009
Identifying genomic regions that descended from a common ancestor is important for understanding the function and evolution of genomes. In distantly related genomes, clusters of homologous gene pairs are evidence of candidate homologous regions. Demonstrating the statistical significance of such "gene clusters" is an essential component of comparative ...
Raghupathy, Narayanan, Durand, Dannie
openaire   +2 more sources

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

open access: yesNature Communications, 2020
Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Jonas Weinmann   +17 more
doaj   +1 more source

Identification of cancer-associated gene clusters and genes via clustering penalization [PDF]

open access: yesStatistics and Its Interface, 2009
Identification of genes associated with cancer development and progression using microarray data is challenging because of the high dimensionality and cluster structure of gene expressions. Here the clusters are composed of multiple genes with coordinated biological functions and/or correlated expressions.
Shuangge, Ma, Jian, Huang, Shihao, Shen
openaire   +2 more sources

Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies

open access: yesStem Cell Reports, 2015
Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in myeloid differentiation.
Nico Lachmann   +16 more
doaj   +1 more source

Complete Genome Sequences and Genome-Wide Characterization of Trichoderma Biocontrol Agents Provide New Insights into their Evolution and Variation in Genome Organization, Sexual Development, and Fungal-Plant Interactions

open access: yesMicrobiology Spectrum, 2021
Trichoderma spp. represent one of the most important fungal genera to mankind and in natural environments. The genus harbors prolific producers of wood-decaying enzymes, biocontrol agents against plant pathogens, plant-growth-promoting biofertilizers, as
Wan-Chen Li   +9 more
doaj   +1 more source

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency

open access: yesStem Cell Reports, 2016
Induced pluripotent stem cells (iPSCs) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). We here describe a robust and efficient protocol to obtain mature and functional Mφ from healthy as well as disease ...
Adele Mucci   +13 more
doaj   +1 more source

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