Results 11 to 20 of about 9,738,594 (396)
Co-Regulated Genes and Gene Clusters [PDF]
There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with
Sergey V. Razin +3 more
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Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme
Fusicoccane-type terpenoids are a subgroup of diterpenoids featured with a unique 5-8-5 ring system. They are widely distributed in nature and possess a variety of biological activities.
Jia-Hua Huang +9 more
doaj +1 more source
Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity
Plants produce phylogenetically and spatially restricted, as well as structurally diverse specialized metabolites via multistep metabolic pathways.
P. Fan +10 more
semanticscholar +1 more source
Supervised clustering of genes [PDF]
We focus on microarray data where experiments monitor gene expression in different tissues and where each experiment is equipped with an additional response variable such as a cancer type. Although the number of measured genes is in the thousands, it is assumed that only a few marker components of gene subsets determine the type of a tissue.
Marcel, Dettling, Peter, Bühlmann
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Gene Cluster Statistics with Gene Families [PDF]
Identifying genomic regions that descended from a common ancestor is important for understanding the function and evolution of genomes. In distantly related genomes, clusters of homologous gene pairs are evidence of candidate homologous regions. Demonstrating the statistical significance of such "gene clusters" is an essential component of comparative ...
Raghupathy, Narayanan, Durand, Dannie
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Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Jonas Weinmann +17 more
doaj +1 more source
Identification of cancer-associated gene clusters and genes via clustering penalization [PDF]
Identification of genes associated with cancer development and progression using microarray data is challenging because of the high dimensionality and cluster structure of gene expressions. Here the clusters are composed of multiple genes with coordinated biological functions and/or correlated expressions.
Shuangge, Ma, Jian, Huang, Shihao, Shen
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Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in myeloid differentiation.
Nico Lachmann +16 more
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Trichoderma spp. represent one of the most important fungal genera to mankind and in natural environments. The genus harbors prolific producers of wood-decaying enzymes, biocontrol agents against plant pathogens, plant-growth-promoting biofertilizers, as
Wan-Chen Li +9 more
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Induced pluripotent stem cells (iPSCs) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). We here describe a robust and efficient protocol to obtain mature and functional Mφ from healthy as well as disease ...
Adele Mucci +13 more
doaj +1 more source

