Results 21 to 30 of about 8,793,913 (366)
Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme
Beilstein Journal of Organic Chemistry, 2022 Fusicoccane-type terpenoids are a subgroup of diterpenoids featured with a unique 5-8-5 ring system. They are widely distributed in nature and possess a variety of biological activities.
Jia-Hua Huang +9 more
doaj +1 more source
antiSMASH 6.0: improving cluster detection and comparison capabilities
Nucleic Acids Res., 2021 Many microorganisms produce natural products that form the basis of antimicrobials, antivirals, and other drugs. Genome mining is routinely used to complement screening-based workflows to discover novel natural products.
K. Blin +6 more
semanticscholar +1 more source
Conversion events in gene clusters [PDF]
BMC Evolutionary Biology, 2011 Gene clusters containing multiple similar genomic regions in close proximity are of great interest for biomedical studies because of their associations with inherited diseases. However, such regions are difficult to analyze due to their structural complexity and their complicated evolutionary histories, reflecting a variety of large-scale mutational ...
Song, G. +9 more
openaire +4 more sources
SnapShot: Imprinted Gene Clusters [PDF]
Cell, 2007 The majority of imprinted genes are found in conserved clusters in the mammalian genome. Shown are mouse imprinted genes that are part of larger imprinting clusters (variations in hum cluster has a prominent gene indicated in the left most column and one or more noncoding (nc)RNAs, which in many cases are critical for the domain-wide regulation of the ...
Joanne L. Thorvaldsen +1 more
openaire +2 more sources
Identification of cancer-associated gene clusters and genes via clustering penalization [PDF]
Statistics and Its Interface, 2009 Identification of genes associated with cancer development and progression using microarray data is challenging because of the high dimensionality and cluster structure of gene expressions. Here the clusters are composed of multiple genes with coordinated biological functions and/or correlated expressions.
Shihao Shen, Shuangge Ma, Jian Huang
openaire +3 more sources
Nature Communications, 2020 Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Jonas Weinmann +17 more
doaj +1 more source
Microbiology Spectrum, 2021 Trichoderma spp. represent one of the most important fungal genera to mankind and in natural environments. The genus harbors prolific producers of wood-decaying enzymes, biocontrol agents against plant pathogens, plant-growth-promoting biofertilizers, as
Wan-Chen Li +9 more
doaj +1 more source
Microbiology Spectrum, 2022 Bacillus velezensis HNA3, a potential plant growth promoter and biocontrol rhizobacterium, was isolated from plant rhizosphere soils in our previous work. Here, we sequenced the entire genome of the HNA3 strain and performed a comparative genome analysis.
Doaa S. Zaid +4 more
doaj +1 more source
Stem Cell Reports, 2015 Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in myeloid differentiation.
Nico Lachmann +16 more
doaj +1 more source
Dynamic Clustering of Gene Expression [PDF]
ISRN Bioinformatics, 2012 It is well accepted that genes are simultaneously involved in multiple biological processes and that genes are coordinated over the duration of such events. Unfortunately, clustering methodologies that group genes for the purpose of novel gene discovery fail to acknowledge the dynamic nature of biological processes and provide static clusters, even ...
Rebecca W. Doerge, Lingling An
openaire +2 more sources