Results 311 to 320 of about 8,793,913 (366)
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Clustering of hypermethylated genes in neuroblastoma
Genes, Chromosomes and Cancer, 2003AbstractCpG‐island hypermethylation of gene promoters is a frequent mechanism for gene inactivation in tumors. Many neuroblastomas have hypermethylation and down‐regulation of CASP8, leading to resistance to tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL). We recently found hypermethylation of the four TRAIL receptors in 9 neuroblastoma
Saskia van Bezouw +6 more
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Journal of Experimental Zoology, 2000
Homeobox genes encode important developmental control proteins. The Drosophila fruit fly HOM complex genes are clustered in region 84-89 of chromosome 3. Probably due to large-scale genome duplication events, their human HOX orthologs belong to four paralogous regions.
Cornel Popovici +3 more
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Homeobox genes encode important developmental control proteins. The Drosophila fruit fly HOM complex genes are clustered in region 84-89 of chromosome 3. Probably due to large-scale genome duplication events, their human HOX orthologs belong to four paralogous regions.
Cornel Popovici +3 more
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Tandem genes and clustered genes
Journal of Theoretical Biology, 1995Two patterns of gene repetition are described: tandem arraying and clustering. Tandemly arrayed genes reside within segments of DNA that are repeated head-to-tail a number of times. Clustered genes are linked but irregularly spaced, are often mutually inverted in an unpredictable pattern and are connected by non-conserved DNA.
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2006
The availability of microarray technology at an affordable price makes it possible to determine expression of several thousand genes simultaneously. Gene expression can be clustered so as to infer the regulatory modules and functionality of a gene relative to one or more of the annotated genes of the same cluster.
John Noel Clifford +2 more
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The availability of microarray technology at an affordable price makes it possible to determine expression of several thousand genes simultaneously. Gene expression can be clustered so as to infer the regulatory modules and functionality of a gene relative to one or more of the annotated genes of the same cluster.
John Noel Clifford +2 more
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Computational Statistics & Data Analysis, 2006
Genes that are more closely spaced on the chromosome than expected by chance are said to be spatially clustered. Standard tests of clustering versus uniformity do not take into account two important features of genes-the high variability of gene length and the low probability that gene locations overlap (exclusion).
Laura Elnitski +2 more
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Genes that are more closely spaced on the chromosome than expected by chance are said to be spatially clustered. Standard tests of clustering versus uniformity do not take into account two important features of genes-the high variability of gene length and the low probability that gene locations overlap (exclusion).
Laura Elnitski +2 more
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Consistency of Sequence-Based Gene Clusters
Journal of Computational Biology, 2010In comparative genomics, differences or similarities of gene orders are determined to predict functional relations of genes or phylogenetic relations of genomes. For this purpose, various combinatorial models can be used to specify gene clusters--groups of genes that are co-located in a set of genomes.
Wittler, Roland +3 more
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A gene cluster of the ochratoxin A biosynthetic genes inPenicillium [PDF]
Mycotoxin Research, 2006 A putative ochratoxin A (OTA) biosynthetic gene cluster inP. nordicum has been identified. The first part of the gene cluster is located on a DNA fragment of 10 kb in length and harbours three genes. A gene with high homology to an alkaline serine protease gene (accession number AY557343), which represents the upstream border of the cluster ...
A. Karolewiez +2 more
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tRNA2Lys gene clusters in Drosophila
Journal of Molecular Biology, 1981Abstract We have isolated segments of Drosophila melanogaster DNA that contain two clusters of tRNA 2 Lys genes. In one segment, pPW511, there is a cluster of three of these genes surrounded by other tRNA genes. Two other segments, pPW516 and pPW541. share a 3 × 10 3 base-pair region that has a cluster of four tRNA 2 Lys genes. This cluster is
Pieter C. Wensink +2 more
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A metabolic force for gene clustering
Bulletin of Mathematical Biology, 2004Bacterial chromosomes frequently contain arrays of contiguous genes that group according to related metabolic roles. We propose that clustering of genes for metabolically related functions confers thermodynamic advantage to the organism based upon our protein immobility model (PIM) of intracellular diffusion.
R.E. Svetic +4 more
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Genomics of the HOX gene cluster
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2002The Hox family of homeobox genes encode transcription factors that control different aspects of metazoan development. They appear clustered in the genomes of those animals in which their relative positions have been mapped. Although clustering is assumed to be a general property of Hox genes in all bilaterians, just a few species have been studied in ...
Chris T. Amemiya, Pedro Martinez
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