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Clustering Gene Expression Patterns
Journal of Computational Biology, 1999Recent advances in biotechnology allow researchers to measure expression levels for thousands of genes simultaneously, across different conditions and over time. Analysis of data produced by such experiments offers potential insight into gene function and regulatory mechanisms.
Amir Ben-Dor, Ron Shamir, Zohar Yakhini
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Mycotoxin Genetics and Gene Clusters [PDF]
European Journal of Plant Pathology, 2002 Fungi produce low molecular weight secondary metabolites such as antibiotics and mycotoxins. Antibiotics cure diseases whereas mycotoxins cause diseases in plants, animals and human beings. Species such as Aspergillus, Fusarium, Penicillium and Stachybotrys are known to produce mycotoxins that accumulate in processed foods and feeds, although the ...
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Evolution of the aflatoxin gene cluster
Mycotoxin Research, 2006WhyAspergillus species produce aflatoxin remains an unsolved question. In this report we suggest that evolution of the aflatoxin biosynthesis gene cluster has been a multistep process. More than 300 million years ago a primordial cluster of genes allowed production of anthraquinones that may have served as insect attractants to facilitate spore ...
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Consensus Clustering in Gene Expression
2015In data analysis, clustering is the process of finding groups in unlabelled data according to similarities among them in such a way that data items belonging to the same group are more similar between each other than items in different groups. Consensus clustering is a methodology for combining different clustering solutions from the same data set in a
GALDI, PAOLA +2 more
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Hox genes, clusters and collinearity
The International Journal of Developmental Biology, 2018This year marks the 40th anniversary of the discovery by Ed Lewis of the property of collinearity in the bithorax gene complex in Drosophila. This landmark work illustrated the need to understand regulatory mechanisms that coordinate expression of homeotic gene clusters.
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Microarray and Gene-Clustering Analysis
2005Human mast cells are capable of secreting a plethora of inflammatory mediators and cytokines that may play a pivotal role in innate immune and inflammatory responses. Activation of mast cells by antigen and immunoglobulin E (IgE) results in signaling, gene expression, and expression of inflammatory mediators.
Shau Ku Huang +2 more
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Algorithms for Finding Gene Clusters
2001Comparing gene orders in completely sequenced genomes is a standard approach to locate clusters of functionally associated genes. Often, gene orders are modeled as permutations. Given k permutations of n elements, a k-tuple of intervals of these permutations consisting of the same set of elements is called a common interval.
Heber, Steffen, Stoye, Jens
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Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching.
Nature Chemical Biology, 2016C. Dejong +8 more
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
exaly