Results 51 to 60 of about 8,793,913 (366)

Exploration of Secondary Metabolite Production Potential in Actinobacteria Isolated From Kandelia candel Mangrove Plant

Frontiers in Marine Science, 2022
Mangroves are extreme inter-tidal environments containing rich microbial communities. Actinobacteria from mangroves have an unprecedented ability to biosynthesize secondary metabolites.
Dini Hu, Dini Hu, Simon Ming-Yuen Lee, Kai Li, Kai Meng Mok   +4 more
doaj   +1 more source

Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria

mBio, 2015
Elucidation of the molecular mechanisms underlying the human gut microbiota's effects on health and disease has been complicated by difficulties in linking metabolic functions associated with the gut community as a whole to individual microorganisms and ...
A. Martínez-del Campo, Smaranda Bodea, H. A. Hamer, J. A. Marks, Henry J. Haiser, P. Turnbaugh, E. Balskus   +6 more
semanticscholar   +1 more source

Mutational analysis of a phenazine biosynthetic gene cluster in Streptomyces anulatus 9663

Beilstein Journal of Organic Chemistry, 2012
The biosynthetic gene cluster for endophenazines, i.e., prenylated phenazines from Streptomyces anulatus 9663, was heterologously expressed in several engineered host strains derived from Streptomyces coelicolor M145.
Orwah Saleh, Katrin Flinspach, Lucia Westrich, Andreas Kulik, Bertolt Gust, Hans-Peter Fiedler, Lutz Heide   +6 more
doaj   +1 more source

Diversity of Gene Clusters for Polyketide and Nonribosomal Peptide Biosynthesis Revealed by Metagenomic Analysis of the Yellow Sea Sediment

Frontiers in Microbiology, 2018
Polyketides (PKs) and nonribosomal peptides (NRPs) are widely applied as drugs in use today, and one potential source for novel PKs and NRPs is the marine sediment microbes.
Yongjun Wei, Lei Zhang, Zhihua Zhou, Xing Yan   +3 more
doaj   +1 more source

Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system

Microbial Cell Factories, 2015
BackgroundDirect cloning combined with heterologous expression of a secondary metabolite biosynthetic gene cluster has become a useful strategy for production improvement and pathway modification of potentially valuable natural products present at minute
Hee-Ju Nah, Min-Woo Woo, Sisun Choi, Eung-Soo Kim   +3 more
semanticscholar   +1 more source

Genetic and Biochemical Evidence That Enterococcus faecalis Gr17 Produces a Novel and Sec-Dependent Bacteriocin, Enterocin Gr17

Frontiers in Microbiology, 2019
Bacteriocins are ribosomally synthesized antibacterial peptides or proteins from microorganisms. We report a novel bacteriocin producing strain, Enterococcus faecalis Gr17, that was isolated from the Chinese traditional low-salt fermented whole fish ...
Guorong Liu, Yao Wang, Xue Li, Xu Hao, Duoxia Xu, Yingning Zhou, Arshad Mehmood, Chengtao Wang   +7 more
doaj   +1 more source

Linkage Mapping and Genome-Wide Association Studies of the Rf Gene Cluster in Sunflower (Helianthus annuus L.) and Their Distribution in World Sunflower Collections

Frontiers in Genetics, 2019
Commercial hybrid seed production in sunflower currently relies on a single cytoplasmic male sterility (CMS) source, PET1 and the major fertility restoration gene, Rf1, leaving the crop highly vulnerable to issues with genetic bottlenecks.
Zahirul I. Talukder, Guojia Ma, Brent S. Hulke, Chao-Chien Jan, Lili Qi   +4 more
doaj   +1 more source

Contrasting Strategies for Sucrose Utilization in a Floral Yeast Clade

mSphere, 2022
Yeast species in the Wickerhamiella and Starmerella genera (W/S clade) thrive in the sugar-rich floral niche. We have previously shown that species belonging to this clade harbor an unparalleled number of genes of bacterial origin, among which is the ...
Carla Gonçalves, Margarida Marques, Paula Gonçalves   +2 more
doaj   +1 more source

The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function

Scientific Reports, 2017
Suppression of therapeutic transgene expression from retroviral gene therapy vectors by epigenetic defence mechanisms represents a problem that is particularly encountered in pluripotent stem cells (PSCs) and their differentiated progeny.
Jessica Kunkiel, Natascha Gödecke, Mania Ackermann, Dirk Hoffmann, Axel Schambach, Nico Lachmann, Dagmar Wirth, Thomas Moritz   +7 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source