Results 101 to 110 of about 8,692,782 (389)

Plant‐derived exosomes extracted from Lycium barbarum L. loaded with isoliquiritigenin to promote spinal cord injury repair based on 3D printed bionic scaffold

Bioengineering & Translational Medicine
Plant‐derived exosomes (PEs) possess an array of therapeutic properties, including antitumor, antiviral, and anti‐inflammatory capabilities. They are also implicated in defensive responses to pathogenic attacks.
Qilong Wang, Kai Liu, Xia Cao, Wanjin Rong, Wenwan Shi, Qintong Yu, Wenwen Deng, Jiangnan Yu, Ximing Xu   +8 more
doaj   +1 more source

Polymeric Mesoporous Silica Nanoparticles for Enhanced Delivery of 5-Fluorouracil In Vitro

Pharmaceutics, 2019
There is a need for the improvement of conventional cancer treatment strategies by incorporation of targeted and non-invasive procedures aimed to reduce side-effects, drug resistance, and recurrent metastases. The anti-cancer drug, 5-fluorouracil (5-FU),
Thashini Moodley, Moganavelli Singh
doaj   +1 more source

Lipid Nanoparticle Acts as a Potential Adjuvant for Influenza Split Vaccine without Inducing Inflammatory Responses

Vaccines, 2020
Vaccination is a critical and reliable strategy for controlling the spread of influenza viruses in populations. Conventional seasonal split vaccines (SVs) for influenza evoke weaker immune responses than other types of vaccines, such as inactivated whole-
Seiki Shirai, Atsushi Kawai, Meito Shibuya, Lisa Munakata, Daiki Omata, Ryo Suzuki, Yasuo Yoshioka   +6 more
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-associated Virus, and Lentiviral Vectors after Intravenous and Direct Kidney Injections.

Human Gene Therapy, 2019
There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due in part to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are ...
J. Rubin, Tien V. Nguyen, Kari L. Allen, K. Ayasoufi, M. Barry   +4 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Gene Delivery to Joints by Intra-Articular Injection.

Human Gene Therapy, 2018
Most forms of arthritis are incurable, difficult to treat, and a major cause of disability in Western countries. Better local treatment of arthritis is impaired by the pharmacokinetics of the joint that make it very difficult to deliver drugs to joints ...
C. Evans, S. Ghivizzani, P. Robbins
semanticscholar   +1 more source

Advances in Gene Delivery Systems [PDF]

BioMed Research International, 2015
Gene therapy can be defined as incorporation of genetic material, that is, DNA or RNA, in the cellular gene regulation system, either to correct the expression of a malfunctioning gene or to modulate the cellular functions through expression of the newly incorporated gene. Nucleic acids (NAs) to correct/block malfunctioning genes have great therapeutic
Surendra Nimesh, Nagendra Kumar Kaushik, Pradeep Kumar, Sabina Halappanavar   +3 more
openaire   +3 more sources

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Allen, James M., Baker, Andrew H., Chamberlain, Jeffrey S., Craig, Margaret Anne, Dominiczak, Anna F., Gilday, Kirsten, Graham, Delyth, Gregorevic, Paul, Masson, Rachel, McBride, Martin, Napoli, Claudio, Nicklin, Stuart A., Smith, Godfrey   +12 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source