Results 121 to 130 of about 4,269,896 (304)
Improved nonviral gene vectors: Efficient and non-toxic polyplexes with enhanced endosomolytic activity [PDF]
, 2005 For the development of improved polyethylenimine (PEI) polyplexes towards ‘artificial viruses’ two key issues are i) to improve the toxicity profile of the applied vectors and ii) to enhance endosomal release, one of the major barriers to efficient gene ...
Boeckle, Sabine
core +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Design of folic acid, transferrin, and integrin receptor specific polyamidoamine dendrimers for gene delivery [PDF]
, 2012 Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-06-14T15:37:18Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No.
Hwang, Mark
core
AAV gene replacement therapy for treating MPS IIIC: Facilitating bystander effects via EV‐mRNA cargo
Journal of Extracellular VesiclesMPS IIIC is a lysosomal storage disease caused by mutations in heparan‐α‐glucosaminide N‐acetyltransferase (HGSNAT), for which no treatment is available.
Tierra A. Bobo +6 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Senescence-associated LncRNAs TRMP and TRMP-S promote gastric cancer by activating IGFL4
Scientific ReportsLncRNAs are important regulators of various cellular processes and have gained much attention for being used as molecular markers in various cancers. Here, we explained the novel role of lncRNA TRMP and its splice variant lncRNA TRMP-S in gastric cancer ...
Mengfei Zhang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Probing recombinant AAV capsid integrity and genome release after thermal stress by mass photometry
Molecular Therapy: Methods & Clinical DevelopmentAdeno-associated viruses (AAVs) are gaining traction as delivery vehicles for gene therapy although the molecular understanding of AAV-transgene release is still limited.
Eduard H.T.M. Ebberink +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source