Results 51 to 60 of about 8,692,782 (389)
Rapid construction of mycobacterial mutagenesis vectors using ligation-independent cloning [PDF]
, 2010 Targeted mutagenesis is one of the major tools for determining the function of a given gene and its involvement in bacterial pathogenesis. In mycobacteria, gene deletion is often accomplished by using allelic exchange techniques that commonly utilise a ...
Balhana, Ricardo +4 more
core +2 more sources
Pharmaceutics, 2021 Nanotechnology has emerged as a promising treatment strategy in gene therapy, especially against diseases such as cancer. Gold nanoparticles (AuNPs) are regarded as favorable gene delivery vehicles due to their low toxicity, ease of synthesis and ability
Calrin Joseph +3 more
doaj +1 more source
Recent Advances in Chitosan-Based Carriers for Gene Delivery
Marine Drugs, 2019 Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions.
Ye Cao +4 more
semanticscholar +1 more source
Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy
Pharmaceutics, 2022 Cancer is among the leading causes of mortality globally, with nearly 10 million deaths in 2020. The emergence of nanotechnology has revolutionised treatment strategies in medicine, with rigorous research focusing on designing multi-functional ...
Seipati Rosemary Mokhosi +3 more
doaj +1 more source
Biomaterials to gene delivery [PDF]
Journal of Controlled Release, 2011 It has been over 40 years since I started biomaterials research. This article is a short summary of past research in my laboratory.
openaire +3 more sources
Combining hyaluronic acid with chitosan enhances gene delivery [PDF]
, 2014 The low gene transfer efficiency of chitosan-DNA polyplexes is a consequence of their high stability and consequent slow DNA release. The incorporation of an anionic polymer is believed to loosen chitosan interactions with DNA and thus promote higher ...
Bitoque, Diogo +2 more
core +3 more sources
Nature Neuroscience, 2017 Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer. Nevertheless, AAVs that provide efficient transduction across specific organs or cell populations are needed.
Ken Y. Chan +10 more
semanticscholar +1 more source
Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition
Frontiers in Molecular Biosciences, 2022 The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes.
Oleg Semenov +6 more
doaj +1 more source
Advanced Drug Delivery Reviews, 2012 Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic strategy. Among its advantages over protein delivery are the potential for directed, sustained and regulated expression of authentically processed, nascent proteins.
openaire +3 more sources
Circumventing antivector immunity: potential use of nonhuman adenoviral vectors [PDF]
, 2014 Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase
Beard C.W. +30 more
core +3 more sources