Results 31 to 40 of about 4,269,896 (304)

Biogenic Synthesis of Silver-Core Selenium-Shell Nanoparticles Using Ocimum tenuiflorum L.: Response Surface Methodology-Based Optimization and Biological Activity

Nanomaterials, 2021
Bimetallic nanoparticles (BNPs) have shown better biological potential compared to their monometallic counterparts owing to the synergistic effect produced by these alloys.
Femi Olawale, Mario Ariatti, Moganavelli Singh   +2 more
doaj   +1 more source

Gene Delivery to Chondrocytes

, 2023
AbstractDelivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the laboratory, for studying the biology of chondrocytes. Advances in gene therapy have created a number of different viral and non-viral vectors for this purpose.
Christopher V, Nagelli, Christopher H, Evans, Rodolfo E, De la Vega   +2 more
openaire   +2 more sources

Freezing Assisted Gene Delivery Combined with Polyampholyte Nanocarriers [PDF]

, 2017
Physical methodologies such as electroporation and the gene-gun technology have been widely used for transfection; however, their applicability is limited because they lead to cell damage and low cell viability. Therefore, to address these limitations we
Tadashi Nakaji-Hirabayashi, Kazuaki Matsumura, Ahmed, Sana, Watanabe, Takayoshi, Takahiro Hohsaka, Hohsaka, Takahiro, Nakaji-Hirabayashi, Tadashi, Matsumura, Kazuaki, Sana Ahmed, Takayoshi Watanabe   +9 more
core   +1 more source

Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo

Drug Delivery, 2021
Pegylated liposomal doxorubicin (PLD) is a representative nanomedicine that has improved tumor selectivity and safety profile. However, the therapeutic superiority of PLD over conventional doxorubicin has been reported to be insignificant in clinical ...
Inoru Yokoe, Daiki Omata, Johan Unga, Ryo Suzuki, Kazuo Maruyama, Yoshiharu Okamoto, Tomohiro Osaki   +6 more
doaj   +1 more source

Gene delivery to the epidermis [PDF]

Human Molecular Genetics, 1997
Epidermal gene delivery techniques are being developed as an experimental approach to understanding the pathogenesis of skin disorders and for developing therapeutic strategies for the treatment of disease. This technology is being evaluated in many clinical trials in the treatment of disorders such as cutaneous melanoma and skin wounding, with 20% of ...
A H, Trainer, M Y, Alexander
openaire   +2 more sources

Decationized polyplexes for gene delivery [PDF]

, 2014
Gene therapy has received much attention in the field of drug delivery. Synthetic, nonviral gene delivery systems have gained increasing attention as vectors for gene therapy mainly due to a favorable immunogenicity profile and ease of manufacturing as ...
Pharmaceutics, Sub Drug delivery, Lammers, Twan Gerardus Gertudis Maria, Sub General Pharmaceutics, Novo, L., Hennink, W.E., Hennink, Wim E., Lammers, Twan, van Nostrum, C.F., Mastrobattista, E., Novo, Luís, UIPS - Utrecht Institute for Pharmaceutical Sciences, van Nostrum, Cornelus F., Mastrobattista, Enrico   +13 more
core   +2 more sources

Histidine-Tagged Folate-Targeted Gold Nanoparticles for Enhanced Transgene Expression in Breast Cancer Cells In Vitro

Pharmaceutics, 2021
Nanotechnology has emerged as a promising treatment strategy in gene therapy, especially against diseases such as cancer. Gold nanoparticles (AuNPs) are regarded as favorable gene delivery vehicles due to their low toxicity, ease of synthesis and ability
Calrin Joseph, Aliscia Daniels, Sooboo Singh, Moganavelli Singh   +3 more
doaj   +1 more source

Secure and effective gene delivery system of plasmid DNA coated by polynucleotide [PDF]

, 2015
Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and ...
Sasaki, Hitoshi, Higuchi, Norihide, Kodama, Yukinobu, Sato, Kayoko, Nakamura, Tadahiro, Kitahara, Takashi, Kurosaki, Tomoaki, Egashira, Kanoko, Fumoto, Shintaro, Ohkubo, Chikako, Nishida, Koyo   +10 more
core   +1 more source

Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

Pharmaceutics, 2022
Cancer is among the leading causes of mortality globally, with nearly 10 million deaths in 2020. The emergence of nanotechnology has revolutionised treatment strategies in medicine, with rigorous research focusing on designing multi-functional ...
Seipati Rosemary Mokhosi, Wendy Mdlalose, Amos Nhlapo, Moganavelli Singh   +3 more
doaj   +1 more source

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
core   +1 more source