Results 11 to 20 of about 498,592 (264)
Gene delivery for immunoengineering
Current Opinion in Biotechnology, 2020 A growing number of gene delivery strategies are being employed for immunoengineering in applications ranging from infectious disease prevention to cancer therapy. Viral vectors tend to have high gene transfer capability but may be hampered by complications related to their intrinsic immunogenicity.
Sarah Y Neshat +2 more
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Hepatocellular-Targeted mRNA Delivery Using Functionalized Selenium Nanoparticles In Vitro
Pharmaceutics, 2021 Selenium’s (Se) chemopreventative and therapeutic properties have attracted attention in nanomedicine. Se nanoparticles (SeNPs) retain these properties of Se while possessing lower toxicity and higher bioavailability, potentiating their use in gene ...
Dhireshan Singh, Moganavelli Singh
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Cold Spring Harbor Protocols, 2011 INTRODUCTIONModern cell biology increasingly relies on molecular tools to facilitate the study of cellular processes. With the advent of recombinant DNA technology, reverse transcription–polymerase chain reaction (RT-PCR) to amplify almost any gene, and fluorescent proteins that can be fused to any desired target protein, the number and scope of ...
David A, Dean, Joshua Z, Gasiorowski
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Anti-c-myc RNAi-Based Onconanotherapeutics
Biomedicines, 2020 Overexpression of the c-myc proto-oncogene features prominently in most human cancers. Early studies established that inhibiting the expression of oncogenic c-myc, produced potent anti-cancer effects.
Saffiya Habib +2 more
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Brain Research Bulletin, 2010 This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection ...
Jinsong, Hao +3 more
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Journal of Nanobiotechnology, 2017 Background The cell source for transplantation therapy is always a prerequisite question to be solved in clinical applications. Neural cells are considered non-regenerable, which highly restrict their application in the treatment for nerve injury ...
Qingtong Yu +10 more
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Pharmaceutical Applications of Molecular Tweezers, Clefts and Clips
Molecules, 2019 Synthetic acyclic receptors, composed of two arms connected with a spacer enabling molecular recognition, have been intensively explored in host-guest chemistry in the past decades.
Amira Mbarek +2 more
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Pharmaceutics, 2019 ：6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism.
Huiyun Zhang +10 more
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Biomedicines, 2020 The development of a biocompatible and nontoxic gene delivery vehicle remains a challenging task. Selenium nanoparticles (SeNPs) have the potential to increase delivery efficiency, to reduce side effects, and to improve therapeutic outcomes.
Fiona Maiyo, Moganavelli Singh
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Biomaterials to gene delivery [PDF]
Journal of Controlled Release, 2011 It has been over 40 years since I started biomaterials research. This article is a short summary of past research in my laboratory.
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