Results 21 to 30 of about 498,592 (264)
Gene delivery to the epidermis [PDF]
Human Molecular Genetics, 1997 Epidermal gene delivery techniques are being developed as an experimental approach to understanding the pathogenesis of skin disorders and for developing therapeutic strategies for the treatment of disease. This technology is being evaluated in many clinical trials in the treatment of disorders such as cutaneous melanoma and skin wounding, with 20% of ...
A H, Trainer, M Y, Alexander
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Pharmaceuticals, 2023 Glioblastoma is a highly invasive and fatal disease. Temozolomide, a blood–brain barrier (BBB)-penetrant therapeutic agent currently used for glioblastoma, does not exhibit sufficient therapeutic effect.
Fumiko Hagiwara +6 more
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Scientific Reports, 2018 With the increasing demand for higher gene carrier performance, a multifunctional vector could immensely simplify gene delivery for disease treatment; nevertheless, the current non- viral vectors lack self-tracking ability.
Xia Cao +13 more
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Recent Advances in Lipid-Based Nanosystems for Gemcitabine and Gemcitabine–Combination Therapy
Nanomaterials, 2021 The anti-metabolite drug gemcitabine is widely used for the treatment of a variety of cancers. At present, gemcitabine is administered as a hydrochloride salt that is delivered by slow intravenous injection in cycles of three or four weeks.
Saffiya Habib, Moganavelli Singh
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Hematology/Oncology Clinics of North America, 1998 Human gene therapy continues to be an exciting concept for the treatment of disease. This field of research remains in its early stages, but already a number of studies have provided "proof-of-principle." Although there is no unequivocal evidence of efficacy, there have been demonstrated physiologic changes that are relevant to the disease process. One
N A, Wivel, J M, Wilson
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Advances in Polymer Technology, 2019 An innovative strategy for the generation of chondrocytes was thoroughly studied in this paper. Polyetherimide-modified polysaccharides of Porphyra yezoensis (pmPPY) served as a nonviral gene vector and delivered Sox9 plasmid to directly reprogram mouse ...
Qingtong Yu +6 more
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Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy
Pharmaceutics, 2021 With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of ...
Thashini Moodley, Moganavelli Singh
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Dendrimers in gene delivery [PDF]
Advanced Drug Delivery Reviews, 2005 Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also make these nanoscaled materials highly interesting for the development of synthetic (non-viral ...
Dufès, Christine +2 more
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Nanomaterials, 2021 Bimetallic nanoparticles (BNPs) have shown better biological potential compared to their monometallic counterparts owing to the synergistic effect produced by these alloys.
Femi Olawale +2 more
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Drug Delivery, 2021 Pegylated liposomal doxorubicin (PLD) is a representative nanomedicine that has improved tumor selectivity and safety profile. However, the therapeutic superiority of PLD over conventional doxorubicin has been reported to be insignificant in clinical ...
Inoru Yokoe +6 more
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