Results 201 to 210 of about 1,025,168 (353)

Additional file 3 of Identification of RPGRIP1L as an instability-maintaining gene to drive tumor growth and PD-L1 expression via Hedgehog signaling in breast cancer

Meng Lv, Yan’e Liu, Weihong Cao, Yongmei Wang, Qi Wang, Xueqiang Gao, Baowei Peng, haibo wang, Yan Mao   +8 more
openalex   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A conjugal gene drive-like system efficiently suppresses antibiotic resistance in a bacterial population. [PDF]

NPJ Antimicrob Resist
Kaduwal S, Stuart EC, Auradkar A, Washabaugh S, Meyer JR, Bier E.   +5 more
europepmc   +1 more source

L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

, 2008
Yu‐San Han, Véronique Lefebvre
openalex   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A simulation-based deep learning framework for spatially explicit malaria modeling of CRISPR suppression gene drive mosquitoes. [PDF]

iScience
Allegretti YH, Sun W, Champer J.
europepmc   +1 more source

Transformative Approaches for Sustainable Weed Management: The Power of Gene Drive and CRISPR-Cas9. [PDF]

Genes (Basel), 2023
Kumam Y, Trick HN, Vara Prasad PV, Jugulam M.   +3 more
europepmc   +1 more source

Additional file 4 of H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

, 2021
Jessica Connacher, Gabrielle A. Josling, Lindsey Orchard, Janette Reader, Manuel Llinás, Lyn‐Marié Birkholtz   +5 more
openalex   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineering gene drive docking sites in a haplolethal locus in Anopheles gambiae. [PDF]

Sci Rep
Smidler AL, Marrogi EA, Scott S, Mameli E, Abernathy D, Akbari OS, Church GM, Catteruccia F, Esvelt K.   +8 more
europepmc   +1 more source