Results 251 to 260 of about 1,025,168 (353)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication. [PDF]

Malar J
Abraham IC, Aboje JE, Ukoaka BM, Tom-Ayegunle K, Amjad M, Abdulkader A, Agbo CE, Akinruli OA, Akisanmi TR, Oyetola EO, Olatunji G, Kokori E, Aderinto N.   +12 more
europepmc   +1 more source

Is CRISPR-based gene drive a biocontrol silver bullet or global conservation threat? [PDF]

, 2015
Bruce L. Webber, S. Raghu, Owain R. Edwards   +2 more
openalex   +1 more source

Boosting 'gene drive' safety [PDF]

Nature, 2015
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Population suppression with dominant female-lethal alleles is boosted by homing gene drive. [PDF]

BMC Biol
Zhu J, Chen J, Liu Y, Xu X, Champer J.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions? [PDF]

Genetics
Rockman MV.
europepmc   +1 more source

Supplementary Table S2 from ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes [PDF]

Hefei Wang, Fangting Zhao, Yao Li, Peiyu Wang, Yixue Wang, Pengfei Ren, Changhe Li, Hanqiu Zheng, Zexian Zeng, Deng Pan   +9 more
openalex   +1 more source

Gene-drive technology needs thorough scrutiny [PDF]

Nature, 2017
openaire   +2 more sources