Results 81 to 90 of about 1,021,897 (307)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
InsectsPopulation replacement refers to the process by which a wild-type population of insect pests is replaced by a population possessing modified traits or abilities.
Yu Zhao +4 more
doaj +1 more source
Genetic Biocontrol for Invasive Species
Frontiers in Bioengineering and Biotechnology, 2020 Invasive species are increasingly affecting agriculture, food, fisheries, and forestry resources throughout the world. As a result of global trade, invasive species are often introduced into new environments where they become established and cause harm ...
John L. Teem +14 more
doaj +1 more source
Gene drive escape from resistance depends on mechanism and ecology
Evolutionary Applications, 2022 Gene drives can potentially be used to suppress pest populations, and the advent of CRISPR technology has made it feasible to engineer them in many species, especially insects.
Forest Cook +2 more
doaj +1 more source
Gene Drive: Past, Present and Future Roads to Vertebrate Biocontrol
Applied Biosciences, 2023 Scientists have long sought a technology to humanely control populations of damaging invasive pests in a species-specific manner. Gene drive technology could see this become a reality.
Gus R. McFarlane +2 more
doaj +1 more source
Integral gene drives for population replacement
Biology Open, 2018 A first generation of CRISPR-based gene drives have now been tested in the laboratory in a number of organisms including malaria vector mosquitoes. Challenges for their use in the area-wide genetic control of vector-borne disease have been identified, including the development of target site resistance, their long-term efficacy in the field, their ...
Alexander Nash +6 more
openaire +5 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Ancestral gene regulatory networks drive cancer [PDF]
Proceedings of the National Academy of Sciences, 2017 Although cancer is one of the most intensively studied phenomena in biology and occurs in almost all multicellular species (1, 2), an explanation for its existence and properties within the context of evolutionary history has received comparatively little attention. However, it is widely recognized that progress in treatment and prevention depends on a
Bussey, Kimberly J +3 more
openaire +3 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Modelling Allee effects in a transgenic mosquito population during range expansion
Journal of Biological Dynamics, 2019 Mosquitoes are vectors for many diseases that cause significant mortality and morbidity. As mosquito populations expand their range, they may undergo mate-finding Allee effects such that their ability to successfully reproduce becomes difficult at low ...
Melody Walker +3 more
doaj +1 more source