Results 81 to 90 of about 1,025,168 (353)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Genetic Biocontrol for Invasive Species

Frontiers in Bioengineering and Biotechnology, 2020
Invasive species are increasingly affecting agriculture, food, fisheries, and forestry resources throughout the world. As a result of global trade, invasive species are often introduced into new environments where they become established and cause harm ...
John L. Teem, Luke Alphey, Sarah Descamps, Matt P. Edgington, Owain Edwards, Neil Gemmell, Tim Harvey-Samuel, Rachel L. Melnick, Kevin P. Oh, Antoinette J. Piaggio, J. Royden Saah, Dan Schill, Paul Thomas, Trevor Smith, Andrew Roberts   +14 more
doaj   +1 more source

Conditions for Investment in Genetic Biocontrol of Pest Vertebrates in Australia

Frontiers in Agronomy, 2022
Managing pest vertebrate species in Australia is a significant challenge for government, industry, research sectors and land-managers. Innovative tools such as genetic biocontrol offers decision-makers a potentially effective means of reducing the impact
Lucy Carter, Lucy Carter, Aditi Mankad, Aditi Mankad, Susan Campbell, Wendy Ruscoe, Wendy Ruscoe, Kevin P. Oh, Kevin P. Oh, Peter R. Brown, Peter R. Brown, Margaret Byrne, Mark Tizard, Mark Tizard, Mark Tizard, Tanja Strive, Tanja Strive   +16 more
doaj   +1 more source

Integral gene drives for population replacement

Biology Open, 2018
A first generation of CRISPR-based gene drives have now been tested in the laboratory in a number of organisms including malaria vector mosquitoes. Challenges for their use in the area-wide genetic control of vector-borne disease have been identified, including the development of target site resistance, their long-term efficacy in the field, their ...
Alexander Nash, Giulia Mignini Urdaneta, Andrea K. Beaghton, Astrid Hoermann, Philippos Aris Papathanos, George K. Christophides, Nikolai Windbichler   +6 more
openaire   +5 more sources

Pairwise gene GO-based measures for biclustering of high-dimensional expression data [PDF]

, 2018
Background: Biclustering algorithms search for groups of genes that share the same behavior under a subset of samples in gene expression data. Nowadays, the biological knowledge available in public repositories can be used to drive these algorithms to
Aguilar Ruiz, Jesús Salvador, Nepomuceno Chamorro, Isabel de los Ángeles, Nepomuceno Chamorro, Juan Antonio, Troncoso Lora, Alicia   +3 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modelling Allee effects in a transgenic mosquito population during range expansion

Journal of Biological Dynamics, 2019
Mosquitoes are vectors for many diseases that cause significant mortality and morbidity. As mosquito populations expand their range, they may undergo mate-finding Allee effects such that their ability to successfully reproduce becomes difficult at low ...
Melody Walker, Julie C. Blackwood, Vicki Brown, Lauren M. Childs   +3 more
doaj   +1 more source

Gene drive escape from resistance depends on mechanism and ecology

Evolutionary Applications, 2022
Gene drives can potentially be used to suppress pest populations, and the advent of CRISPR technology has made it feasible to engineer them in many species, especially insects.
Forest Cook, James J. Bull, Richard Gomulkiewicz   +2 more
doaj   +1 more source

Gene Drive: Past, Present and Future Roads to Vertebrate Biocontrol

Applied Biosciences, 2023
Scientists have long sought a technology to humanely control populations of damaging invasive pests in a species-specific manner. Gene drive technology could see this become a reality.
Gus R. McFarlane, C. Bruce A. Whitelaw, Simon G. Lillico   +2 more
doaj   +1 more source

Ancestral gene regulatory networks drive cancer [PDF]

Proceedings of the National Academy of Sciences, 2017
Although cancer is one of the most intensively studied phenomena in biology and occurs in almost all multicellular species (1, 2), an explanation for its existence and properties within the context of evolutionary history has received comparatively little attention. However, it is widely recognized that progress in treatment and prevention depends on a
Bussey, Kimberly J, Cisneros, Luis H, Lineweaver, Charles, Davies, Paul   +3 more
openaire   +3 more sources