Results 61 to 70 of about 3,726,105 (294)
Regulation of GM Organisms for Invasive Species Control
Frontiers in Bioengineering and Biotechnology, 2020 Invasive species can cause significant harm to the environment, agriculture, and human health, but there are often very limited tools available to control their populations. Gene drives (GD) have been proposed as a new tool which could be used to control
Heidi J. Mitchell, Detlef Bartsch
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Annals of Medicine, 2023 Background: In the era of insecticides and anti-malarial drug resistance, gene drive technology holds considerable promise for malaria control. Gene drive technology deploys genetic modifications into mosquito populations to impede their ability to ...
Yusuf Amuda Tajudeen +7 more
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Applied Biosafety, 2017 Biosafety risk assessment and containment framework strategies for research involving gene drives pose a challenge, as there are no published guidelines or regulatory information yet written specif...
Partha Krishnan, David Gillum
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Rescue by gene swamping as a gene drive deployment strategy
Cell Reports, 2022 Abstract Gene drives are genetic constructs that can spread deleterious alleles with potential application to population suppression of harmful species. Given that a gene drive can potentially spill over to other populations or even other species, control measures and fail-safes strategies must be considered. Gene drives are designed to
Keith D. Harris, Gili Greenbaum
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives
Cell Reports, 2020 Summary: Synthetic CRISPR-based gene-drive systems have tremendous potential in public health and agriculture, such as for fighting vector-borne diseases or suppressing crop pest populations. These elements can rapidly spread in a population by breaching
Víctor López Del Amo +8 more
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OUP: lethal gene drive selects inbreeding [PDF]
Evolution, Medicine, and Public Health, 2016 Abstract The use of ‘selfish’ gene drive systems to suppress or even extinguish populations has been proposed on theoretical grounds for almost half a century. Creating these genes has recently become possible with CRISPR technology. One seemingly feasible approach, originally proposed by Burt, is to create a homing endonuclease gene ...
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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InsectsPopulation replacement refers to the process by which a wild-type population of insect pests is replaced by a population possessing modified traits or abilities.
Yu Zhao +4 more
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Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations
eLife, 2022 Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 provides a highly efficient and flexible genome editing technology with numerous potential applications ranging from gene therapy to population control.
Anna M Langmüller +10 more
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