Results 81 to 90 of about 3,726,105 (294)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Gene drive escape from resistance depends on mechanism and ecology
Evolutionary Applications, 2022 Gene drives can potentially be used to suppress pest populations, and the advent of CRISPR technology has made it feasible to engineer them in many species, especially insects.
Forest Cook +2 more
doaj +1 more source
Evolutionary dynamics of CRISPR gene drives [PDF]
Science Advances, 2016 Abstract The alteration of wild populations has been discussed as a solution to a number of humanity’s most pressing ecological and public health concerns. Enabled by the recent revolution in genome editing, CRISPR gene drives, selfish genetic elements which can spread through populations even if they confer no advantage to their host ...
Charleston Noble +4 more
openaire +4 more sources
Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant
Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke +9 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Evolutionary Applications, 2020 CRISPR‐based gene drives bias inheritance in their favour by inducing double‐stranded breaks (DSBs) at wild‐type homologous loci and using the drive transgene as a repair template—converting drive heterozygotes into homozygotes. Recent studies have shown
Matthew P. Edgington +2 more
doaj +1 more source
Gene expression drives the evolution of dominance [PDF]
Nature Communications, 2017 Abstract Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified.
Christian D. Huber +3 more
openaire +6 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]
, 2008 We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
Joets, Johann +15 more
core +1 more source
Evaluating Gene Drive Approaches for Public Benefit [PDF]
, 2020 Gene drive approaches—those which bias inheritance of a genetic element in a population of sexually reproducing organisms—have the potential to provide important public benefits.
Santos, Michael R., Michael R. Santos
core +1 more source