Results 51 to 60 of about 519,971 (295)

First Steps towards Underdominant Genetic Transformation of Insect Populations

, 2014
The idea of introducing genetic modifications into wild populations of insects to stop them from spreading diseases is more than 40 years old. Synthetic disease refractory genes have been successfully generated for mosquito vectors of dengue fever and ...
Reeves R. Guy, Philipp M. Altrock (340203), Jarosław Bryk, R Guy Reeves, Altrock, P., Jai A. Denton (185794), Jarosław Bryk (47108), Jai A Denton, Bryk, J., R. Guy Reeves (185792), Philipp M Altrock, Bryk, Jarek, Denton Jai A., Reed, F., Denton, Jai A., Floyd A Reed, Floyd A. Reed (185797), Altrock Philipp M., Reed, Floyd A., Altrock, Philipp M., Reeves, R. Guy, Bryk Jarosław, Reed Floyd A., Reeves, R., Denton, J.   +24 more
core   +1 more source

Molecular safeguarding of CRISPR gene drive experiments

eLife, 2019
CRISPR-based homing gene drives have sparked both enthusiasm and deep concerns due to their potential for genetically altering entire species. This raises the question about our ability to prevent the unintended spread of such drives from the laboratory ...
Jackson Champer, Joan Chung, Yoo Lim Lee, Chen Liu, Emily Yang, Zhaoxin Wen, Andrew G Clark, Philipp W Messer   +7 more
doaj   +1 more source

Gene drive strategies of pest control in agricultural systems: Challenges and opportunities

Evolutionary Applications, 2021
Recent advances in gene‐editing technologies have opened new avenues for genetic pest control strategies, in particular around the use of gene drives to suppress or modify pest populations. Significant uncertainty, however, surrounds the applicability of
Mathieu Legros, John M. Marshall, Sarina Macfadyen, Keith R. Hayes, Andy Sheppard, Luke G. Barrett   +5 more
doaj   +1 more source

CRISPR-Clear: A Fieldable Detection Procedure for Potential CRISPR-Cas9 Gene Drive Based Bioweapons

, 2019
Rapid progression in genetic modification research has made gene editing increasingly cheaper and easier to use. CRISPR-Cas9 for example, allows for the specific alteration of the genome of an organism with relative simplicity and low costs.
Vittorio, Saggiomo, Angelina, Horsting, Aldrik, Velders, Jorrit W., Hegge, Martijn M., van Galen, Anna C., Nieuwenweg   +5 more
core   +1 more source

A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. [PDF]

, 2012
Intragenomic conflicts arise when a genetic element favours its own transmission to the detriment of others. Conflicts over sex chromosome transmission are expected to have influenced genome structure, gene regulation, and speciation.
Shantha K. Mahadevaiah (94714), Nabeel A. Affara (135531), Vaiman, Daniel, Julie Cocquet, Nabeel A Affara, Burgoyne, Paul S., Daniel Vaiman, Cocquet, Julie, Affara, Nabeel A., Julie Cocquet (135523), Mahadevaiah, Shantha K., Ellis, Peter J.I., Peter J I Ellis, Shantha K Mahadevaiah, Daniel Vaiman (83223), Paul S. Burgoyne (94717), Peter J. I. Ellis (135526), Paul S Burgoyne   +17 more
core   +1 more source

Tethered homing gene drives: A new design for spatially restricted population replacement and suppression

Evolutionary Applications, 2019
Optimism regarding potential epidemiological and conservation applications of modern gene drives is tempered by concern about the possibility of unintended spread of engineered organisms beyond the target population. In response, several novel gene drive
Sumit Dhole, Alun L. Lloyd, Fred Gould
doaj   +1 more source

In Our Image: The Ethics of CRISPR Genome Editing

Biomolecular Concepts, 2021
The advent of genome editing technology promises to transform human health, livestock and agriculture, and to eradicate pest species. This transformative power demands urgent scrutiny and resolution of the ethical conflicts attached to the creation and ...
Eissenberg Joel C.
doaj   +1 more source

Genomically informed gene drive modelling

, 2022
© 2022 Benjamin James CammCRISPR/Cas gene drives are a focus of genetic biocontrol for pest species. They have the potential to radically affect pest species, by making them more manageable or by eradicating them.
Camm, Benjamin James
core  

CRISPR-based genetic control strategies for insect pests

Journal of Integrative Agriculture, 2023
Genetic control strategies such as the sterile insect technique have successfully fought insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic repeats) technology, together with high-quality genomic resources obtained in ...
Ying YAN, Roswitha A. AUMANN, Irina HÄCKER, Marc F. SCHETELIG   +3 more
doaj   +1 more source

Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control:New directions for gene drive risk governance [PDF]

, 2021
Background: The African Union’s High-Level Panel on Emerging Technologies identified gene drive mosquitoes as a priority technology for malaria elimination. The first field trials are expected in 5–10 years in Uganda, Mali or Burkina Faso. In preparation,
Ledingham, Katie, Smith, Robert D.J., Opesen, Chris, Kokotovich, Adam, Hartley, Sarah, Rwabukwali, Charles B., Raymond, Ben, Habtewold, Tibebu   +7 more
core   +2 more sources