Results 41 to 50 of about 519,971 (295)

Combining gene drive with mass drug administration.

, 2022
(A) 35% reduction in mean worm burden (MWB) is observed in 10 years with gene drive alone. (B) Targeted administration of MDA at 60% annual reduction (efficacy*coverage) in MWB results in more rapid but temporary reduction than the use of gene drive ...
Chloe G. Rickards (14035038), Javier Perez-Saez (819732), Giulio A. De Leo (7871858), Richard E. Grewelle (3284295), Josh Tycko (2737324), Erica K. O. Namigai (8156778)   +5 more
core   +1 more source

Genetic Approaches for Controlling CRISPR-based Autonomous Homing Gene Drives

Frontiers in Bioengineering and Biotechnology, 2022
CRISPR-based autonomous homing gene drives are a potentially transformative technology with the power to reduce the prevalence of, or even eliminate, vector-borne diseases, agricultural pests, and invasive species.
Pratima R. Chennuri, Zach N. Adelman, Kevin M. Myles   +2 more
doaj   +1 more source

Benefits and risks of gene drives for invasive plant management - the case for common tansy

Frontiers in Agronomy, 2023
Invasive plants cause significant environmental and economic damage, but land managers have few control options. Common tansy (Tanacetum vulgare) is prevalent in many US states and is one of the most reported invasive plants in Minnesota.
Lori Croghan, Alan G. Smith, Matthew A. Tancos, Neil O. Anderson, Roger L. Becker   +4 more
doaj   +1 more source

A native promoter–gene fusion created by CRISPR/Cas9-mediated genomic deletion offers a transgene-free method to drive oil accumulation in leaves [PDF]

, 2022
Achieving gain-of-function phenotypes without inserting foreign DNA is an important challenge for plant biotechnologists. Here we show that a gene can be brought under the control of a promoter from an upstream gene by deleting the intervening genomic ...
Eastmond, Peter J., Bhunia, Rupam Kumar, Peter J. Eastmond, Rupam Kumar Bhunia, Menard, G. N., Eastmond, P. J., Bhunia, R. K., Guillaume N. Menard, Menard, Guillaume N.   +8 more
core   +1 more source

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Nature Communications, 2018
The original version of this Article contained an error in the spelling of the author Jonah B Sacha, which was incorrectly given as Jonah Sacha. These errors have now been corrected in both the PDF and HTML versions of the Article.
Lucy C. Walters, Karl Harlos, Simon Brackenridge, Daniel Rozbesky, Jordan R. Barrett, Vitul Jain, Thomas S. Walter, Chris A. O’Callaghan, Persephone Borrow, Mireille Toebes, Scott G. Hansen, Jonah B. Sacha, Shaheed Abdulhaqq, Justin M. Greene, Klaus Früh, Emily Marshall, Louis J. Picker, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie   +19 more
doaj   +1 more source

Regulating gene drives [PDF]

Science, 2014
Regulatory gaps must be filled before gene drives could be used in the ...
Oye, Kenneth A., Esvelt, Kevin, Appleton, Evan, Catteruccia, Flaminia, Church, George, Kuiken, Todd, Lightfoot, Shlomiya Bar-Yam, McNamara, Julie, Smidler, Andrea, Collins, James P.   +9 more
openaire   +1 more source

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
Joets, Johann, Moore, Jonathan D., Heslop-Harrison, J. (John), King , Graham J., Ryder, C. D., Heslop-Harrison, J. S., Joets, J., Bailey, John P., Moore, J., Ryder, Carol D., Bailey, J. P., Alix, K., Barker, G. C., King, G. J., Barker, Guy C., Alix, Karine   +15 more
core   +1 more source

Evaluation of Hydrogen Peroxide Fumigation and Heat Treatment for Standard Emergency Arthropod Inactivation in BSL-3 Insectaries

Frontiers in Bioengineering and Biotechnology, 2020
Climate change and global movements of people and goods have accelerated the spread of invasive species, including insects that vector infectious diseases, which threaten the health of more than half of the world’s population. Increasing research efforts
Irina Häcker, Irina Häcker, Roland Koller, Gerrit Eichner, Jakob Martin, Eleni Liapi, Johanna Rühl, Tanja Rehling, Marc F. Schetelig, Marc F. Schetelig   +9 more
doaj   +1 more source

Next-generation CRISPR gene-drive systems using Cas12a nuclease. [PDF]

Nat Commun, 2023
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-based gene drives, which manipulate insect populations due to their ability to rapidly propagate desired genetic traits into a target population.
Sanz Juste S, Okamoto EM, Nguyen C, Feng X, López Del Amo V.   +4 more
europepmc   +2 more sources

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Nature Communications, 2018
Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8+ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding ...
Lucy C. Walters, Karl Harlos, Simon Brackenridge, Daniel Rozbesky, Jordan R. Barrett, Vitul Jain, Thomas S. Walter, Chris A. O’Callaghan, Persephone Borrow, Mireille Toebes, Scott G. Hansen, Jonah B Sacha, Shaheed Abdulhaqq, Justin M. Greene, Klaus Früh, Emily Marshall, Louis J. Picker, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie   +19 more
doaj   +1 more source