Results 21 to 30 of about 3,726,105 (294)
GGene drives in the U.K., U.S., and Australian press (2015–2019): How a new focus on responsibility is shaping science communication [PDF]
, 2022 Gene drive is a controversial biotechnology for pest control. Despite a commitment from gene drive researchers to responsibility and the key role of the media in debates about science and technology, little research has been conducted on media reporting ...
Nerlich, Brigitte +2 more
core +1 more source
Selfing is the safest sex for Caenorhabditis tropicalis
eLife, 2021 Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions.
Luke M Noble +13 more
doaj +1 more source
Viral gene drive in herpesviruses [PDF]
Nature Communications, 2019 Abstract Herpesviruses are ubiquitous pathogens in need of novel therapeutic solutions. Current engineered gene drive strategies rely on sexual reproduction, and are thought to be restricted to sexual organisms. Here, we report on the design of a novel gene drive system that allows the spread of an engineered trait in populations of DNA
Walter, Marius, Verdin, Eric
openaire +3 more sources
Anopheles gambiae Genome Conservation as a Resource for Rational Gene Drive Target Site Selection
Insects, 2021 The increase in molecular tools for the genetic engineering of insect pests and disease vectors, such as Anopheles mosquitoes that transmit malaria, has led to an unprecedented investigation of the genomic landscape of these organisms.
Nace Kranjc +3 more
doaj +1 more source
The principles driving gene drives for conservation
Environmental Science & Policy, 2022 Gene drive technology is an emerging biotechnology with the potential to address some of the most intractable global biodiversity conservation issues. Scientists are exploring potential gene drive applications for managing invasive species and building resilience in keystone species threatened by climate change.
Hartley, S, Taitingfong, R, Fidelman, P
openaire +4 more sources
Molecular Therapy: Methods & Clinical Development, 2019 rAAVrh74.MCK.GALGT2 is a surrogate gene therapy that inhibits muscular dystrophy in multiple animal models. Here, we report on a dose-response study of functional muscle GALGT2 expression as well as toxicity and biodistribution studies after systemic ...
Deborah A. Zygmunt +10 more
doaj +1 more source
First Steps towards Underdominant Genetic Transformation of Insect Populations [PDF]
, 2014 The idea of introducing genetic modifications into wild populations of insects to stop them from spreading diseases is more than 40 years old. Synthetic disease refractory genes have been successfully generated for mosquito vectors of dengue fever and ...
Reeves R. Guy +24 more
core +2 more sources
NanoEthics, 2023 Abstract Gene drives are potentially ontologically and morally disruptive technologies. The potential to shape evolutionary processes and to eradicate (e.g. malaria-transmitting or invasive) populations raises ontological questions about evolution, nature, and wilderness. The transformative promises and perils of gene drives also raise pressing ethical
Keje Boersma +2 more
openaire +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Recombinant adeno-associated virus (rAAV)rh74.MCK.GALGT2 is a muscle-specific gene therapy that is being developed to treat forms of muscular dystrophy.
Rui Xu +17 more
doaj +1 more source
Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]
, 2010 The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P. +22 more
core +1 more source