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A Code of Ethics for Gene Drive Research [PDF]

The CRISPR Journal, 2021
Gene drives hold promise for use in controlling insect vectors of diseases, agricultural pests, and for conservation of ecosystems against invasive species. At the same time, this technology comes with potential risks that include unknown downstream effects on entire ecosystems as well as the accidental or nefarious spread of organisms that carry the ...
Annas G. J., Beisel C. L., Clement K., Crisanti A., Francis S., Galardini M., Galizi R., Grunewald J., Immobile G., Khalil A. S., Muller R., Pattanayak V., Petri K., Paul L., Pinello L., Simoni A., Taxiarchi C., Joung J. K.   +17 more
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Making gene drive biodegradable [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2020
Gene drive systems have long been sought to modify mosquito populations and thus combat malaria and dengue. Powerful gene drive systems have been developed in laboratory experiments, but may never be used in practice unless they can be shown to be acceptable through rigorous field-based testing. Such testing is complicated by the anticipated difficulty
Josef Zapletal, Neda Najmitabrizi, Madhav Erraguntla, Mark A. Lawley, Kevin M. Myles, Zach N. Adelman   +5 more
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Gene drives gaining speed [PDF]

Nature Reviews Genetics, 2021
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies. Recently developed CRISPR-Cas9-based gene-drive systems are highly efficient in laboratory settings, offering the potential to reduce the prevalence of vector-borne diseases, crop pests and non-native invasive species.
openaire   +4 more sources

Evading resistance to gene drives [PDF]

Genetics, 2020
Abstract Gene drives offer the possibility of altering and even suppressing wild populations of countless plant and animal species, and CRISPR technology now provides the technical feasibility of engineering them. However, population-suppression gene drives are prone to select resistance, should it arise. Here, we develop mathematical
Richard Gomulkiewicz, Micki L. Thies, James J. Bull   +2 more
openaire   +2 more sources

Assessing target genes for homing suppression gene drive. [PDF]

EMBO J
Abstract Gene drives are engineered alleles that bias their own inheritance in offspring, enabling the spread of specific traits throughout a population. Targeting female fertility genes in a gene drive can be an efficient strategy for population suppression.
Xu X, Fang J, Chen J, Yang J, Yang X, Hou S, Sun W, Champer J.   +7 more
europepmc   +3 more sources

The principles driving gene drives for conservation

Environmental Science & Policy, 2022
Gene drive technology is an emerging biotechnology with the potential to address some of the most intractable global biodiversity conservation issues. Scientists are exploring potential gene drive applications for managing invasive species and building resilience in keystone species threatened by climate change.
Hartley, S, Taitingfong, R, Fidelman, P
openaire   +4 more sources

Gene Drives as Interventions into Nature: the Coproduction of Ontology and Morality in the Gene Drive Debate

NanoEthics, 2023
Abstract Gene drives are potentially ontologically and morally disruptive technologies. The potential to shape evolutionary processes and to eradicate (e.g. malaria-transmitting or invasive) populations raises ontological questions about evolution, nature, and wilderness. The transformative promises and perils of gene drives also raise pressing ethical
Keje Boersma, Bernice Bovenkerk, David Ludwig   +2 more
openaire   +1 more source

Moving beyond narrow definitions of gene drive: Diverse perspectives and frames enable substantive dialogue among science and humanities teachers in the United States and United Kingdom

, 2023
Gene drive is an emerging biotechnology with applications in global health, conservation and agriculture. Scientists are preparing for field trials, triggering debate about when and how to release gene-drive organisms.
Barnhill-Dilling, S. Kathleen, Stelmach, Aleksandra, Jason A. Delborne, Hartley, Sarah, Delborne, Jason A., S. Kathleen Barnhill-Dilling, Sarah Hartley, Aleksandra Stelmach   +7 more
core   +1 more source

Viral gene drive in herpesviruses [PDF]

Nature Communications, 2019
Abstract Herpesviruses are ubiquitous pathogens in need of novel therapeutic solutions. Current engineered gene drive strategies rely on sexual reproduction, and are thought to be restricted to sexual organisms. Here, we report on the design of a novel gene drive system that allows the spread of an engineered trait in populations of DNA
Walter, Marius, Verdin, Eric
openaire   +3 more sources

Gene Drives on the Horizon [PDF]

Applied Biosafety, 2016
In June 2016, the National Academies of Sciences, Engineering, and Medicine published a 220-page report from its multidisciplinary Committee on Gene Drive Research in Non-Human Organisms, which add...
Elizabeth Heitman, Keegan Sawyer, James P. Collins   +2 more
openaire   +2 more sources