Results 11 to 20 of about 3,726,105 (294)
Gene drive: progress and prospects [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2019 Gene drive is a naturally occurring phenomenon in which selfish genetic elements manipulate gametogenesis and reproduction to increase their own transmission to the next generation. Currently, there is great excitement about the potential of harnessing such systems to control major pest and vector populations.
Wedell, N, Price, T A R, Lindholm, A K
core +15 more sources
Principles for gene drive research [PDF]
Science, 2017 Sponsors and supporters of gene drive research respond to a National Academies ...
Claudia, Emerson +3 more
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Gene Drive: Evolved and Synthetic [PDF]
ACS Chemical Biology, 2018 Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to-or indeed even if they detract from-organismal survival and reproduction. Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing ...
Burt, Austin, Crisanti, Andrea
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Journal of Responsible Innovation, 2017 When scientists alter the genome of an organism, we typically reduce its ability to reproduce in the wild.
John Min +3 more
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A Code of Ethics for Gene Drive Research [PDF]
The CRISPR Journal, 2021 Gene drives hold promise for use in controlling insect vectors of diseases, agricultural pests, and for conservation of ecosystems against invasive species. At the same time, this technology comes with potential risks that include unknown downstream effects on entire ecosystems as well as the accidental or nefarious spread of organisms that carry the ...
Annas G. J. +17 more
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Frontiers in Bioengineering and Biotechnology, 2023 Gene drive-modified mosquitoes (GDMMs) are proposed as new tools for control and elimination of malaria and other mosquito-borne diseases, and promising results have been observed from testing conducted in containment. Although still at an early stage of
Stephanie L. James +3 more
doaj +1 more source
Moving beyond narrow definitions of gene drive: Diverse perspectives and frames enable substantive dialogue among science and humanities teachers in the United States and United Kingdom [PDF]
, 2023 Gene drive is an emerging biotechnology with applications in global health, conservation and agriculture. Scientists are preparing for field trials, triggering debate about when and how to release gene-drive organisms.
Barnhill-Dilling, S. Kathleen +7 more
core +1 more source
Making gene drive biodegradable [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2020 Gene drive systems have long been sought to modify mosquito populations and thus combat malaria and dengue. Powerful gene drive systems have been developed in laboratory experiments, but may never be used in practice unless they can be shown to be acceptable through rigorous field-based testing. Such testing is complicated by the anticipated difficulty
Josef Zapletal +5 more
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Gene drives gaining speed [PDF]
Nature Reviews Genetics, 2021 Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies. Recently developed CRISPR-Cas9-based gene-drive systems are highly efficient in laboratory settings, offering the potential to reduce the prevalence of vector-borne diseases, crop pests and non-native invasive species.
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Evading resistance to gene drives [PDF]
Genetics, 2020 Abstract Gene drives offer the possibility of altering and even suppressing wild populations of countless plant and animal species, and CRISPR technology now provides the technical feasibility of engineering them. However, population-suppression gene drives are prone to select resistance, should it arise. Here, we develop mathematical
Richard Gomulkiewicz +2 more
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